Back to Trials
NCT07503210PHASE3Recruiting

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Novo Nordisk A/S

Start Date

4/21/2026

Completion Date

7/4/2028

Summary

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.

Interventions

DRUG

NNC0487-0111

DRUG

Placebo (matched to NNC0487-0111)

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Obesity

Locations

Pinnacle Research Group LLC

Anniston, Alabama 36207

United States

Diablo Clinical Research, Inc.

Walnut Creek, California 94598

United States

Florida Inst For Clin Res LLC

Orlando, Florida 32825

United States

Endeavor Health

Skokie, Illinois 60077

United States

Midwest Inst For Clin Res

Indianapolis, Indiana 46260

United States

Medication Mgmnt, LLC_Grnsboro

Greensboro, North Carolina 27405

United States

PMG Research of Wilmington LLC

Wilmington, North Carolina 28401

United States

UPA Ctr Weight and Eating Dis

Philadelphia, Pennsylvania 19104

United States

Clinical Res Collaborative

Cumberland, Rhode Island 02864

United States

North Texas Endocrine Center

Dallas, Texas 75231

United States

UT Southwestern Med Cntr

Dallas, Texas 75390-9302

United States

Selma Medical Associates

Winchester, Virginia 22601-3834

United States

Rainier Clin Res Ctr Inc

Renton, Washington 98057

United States

Conexa

Ciudad Autonoma de Buenos Aires, Buenos Aires C1018ADE

Argentina

CICEMO- Consultorio (Av Directorio)

Ciudad Autónoma de Buenos Aires, Buenos Aires C1424CIQ

Argentina

Instituto de Investigaciones Clinicas Mar Del Plata

Mar del Plata, Buenos Aires B7600FZN

Argentina

CIPREC Pueyrredon

Buenos Aires, C1119ACN

Argentina

Sydney Clinical Trials

Campbelltown, New South Wales 2560

Australia

Sydney Cardiometabolic Centre

Liverpool, New South Wales 2170

Australia

Hunter Diabetes Centre

Merewether, New South Wales 2291

Australia

Nightingale Research

Adelaide, South Australia 5000

Australia

Anima Research Center

Diepenbeek, 3590

Belgium

AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie

Kortrijk, 8500

Belgium

Centre hospitalier universitaire de Liège (CHU de Liège)

Liège, 4000

Belgium

AZ OOSTENDE (Campus DAMIAAN)

Ostend, 8400

Belgium

DCC 1 - Lom EOOD

Lom, 3600

Bulgaria

MHAT Med Line Clinic

Plovdiv, 4000

Bulgaria

UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic

Plovdiv, 4001

Bulgaria

AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD

Plovdiv, 4002

Bulgaria

SGHAT Dr. Shterev EOOD

Sofia, 1330

Bulgaria

UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases

Sofia, 1431

Bulgaria

Medical Center Maraya Med EOOD

Sofia, 1756

Bulgaria

AIPSMC Dr. Traykovska EOOD

Sofia, 1839

Bulgaria

Sjællands Universitetshospital, Køge - Medicinsk Afdeling

Køge, Region Sjælland 4600

Denmark

Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden

Esbjerg, Region Syddanmark 6700

Denmark

Sanos Clinic - Vejle

Vejle, Region Syddanmark 7100

Denmark

CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition

Clermont-Ferrand, 63000

France

CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition

La Tronche, 38700

France

GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie

Le Creusot, 71200

France

CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne

Lille, 59000

France

CHU DE POITIERS_Centre d'investigation Clinique

Poitiers, 86000

France

Diabetologikum - Diabetologische Schwerpunktpraxis Dr. Thomas Segiet

Speyer, LÄK Rheinland-Pfalz 67346

Germany

Wendisch - Dahl Hamburg - DZHW

Hamburg, 22607

Germany

Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH

Leipzig, 04103

Germany

Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz

Lingen, 49808

Germany

Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

Münster, 48145

Germany

RED-Institut für medizinische Forschung und Fortbildung GmbH

Oldenburg in Holstein, 23758

Germany

Zentrum für klinische Studien Alexander Segner

Saint Ingbert-Oberwürzbach, 66386

Germany

Arcispedale Sant'Anna (Cona) - UO di Endocrinologia

Ferrara, Emilia-Romagna 44124

Italy

IRCCS Ospedale Policlinico San Martino - Medicina Interna e Specialità Mediche

Genoa, Liguria 16132

Italy

Fondazione Salvatore Maugeri I.R.C.C.S. - Pavia - Dipartimento Medicina Interna e Generale

Pavia, Lombardy 27100

Italy

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - Presidio Villa Belmonte

Palermo, Sicily 90127

Italy

Azienda Ospedaliera di Padova - UOSD Chirurgia Bariatrica

Padova, Veneto 35128

Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Geriatria

Verona, Veneto 37126

Italy

A.O.Universitaria S.ORSOLA-MALPIGHI - U.O.Endocrinologia e Cura

Bologna, 40138

Italy

IRCCS Humanitas - U.O. Endocrinologia e Diabetologia

Rozzano (MI), 20089

Italy

PreCare Trial & Recruitment

Born, Limburg 6121 XK

Netherlands

Progress Clinical Research Den Bosch

's-Hertogenbosch, North Brabant 5223 LA

Netherlands

EB Flevo Research BV

Almere Stad, 1311RL

Netherlands

Meander MC

Amersfoort, 3813 TZ

Netherlands

Rijnstate Ziekenhuis

Arnhem, 6815 AD

Netherlands

Centro Periferico De Especialidades Bola Azul

Almería, 04009

Spain

Hospital Clinic i Provincial

Barcelona, 08036

Spain

H. de León_Endocrinología

León, 24008

Spain

Hospital Clínico San Carlos

Madrid, 28040

Spain

H. Clinico Univ. Virgen de la Victoria

Málaga, 29010

Spain

H.U. Quirónsalud Madrid

Pozuelo de Alarcón, 28223

Spain

Hospital Universitario Virgen del Rocío

Seville, 41013

Spain

EMS Healthcare

Cheshire, CH65 4LE

United Kingdom

Clifton Medical Centre

Rotherham, S65 1DA

United Kingdom

Staploe Medical Centre

Soham, CB7 5JD

United Kingdom

Albany House Medical Centre

Wellingborough, NN8 4RW

United Kingdom