NCT07544628PHASE1RecruitingAccepts Healthy Volunteers
A Phase 1 Study of Navlimetostat Tablet Formulations
Bristol-Myers Squibb
Start Date
4/27/2026
Completion Date
10/15/2026
Summary
This study aims to compare the PK of Navlimetostat after administration of a wet-granulation tablet versus the dry-granulation tablet formulation in healthy adult female
Eligibility Criteria
Age Range: 18 years to 55 years
Inclusion Criteria:
* Participants must be healthy adult INOCBP female with no clinically significant findings on medical history, PE, VS, 12-lead ECGs, or clinical laboratory determinations, as assessed by the investigator.
* Participants must have BMI of 18.0 to 35.0 kg/m2.
* Participants must have adequate laboratory test results for renal and hepatic function, as assessed by the investigator, defined as eGFR ≥ 90 mL/min/1.73m2 using the CKD-EPI equation (screening only), and total bilirubin, ALP, GGT, AST, ALT ≤ 1.5 × ULN.
Exclusion Criteria:
* Participant must not have any significant acute or chronic medical illness (in the assessment of the investigator).
* Participant must not have current or recent GI disease: Any gastrointestinal disease within 3 months of study intervention administration that could possibly affect drug absorption, distribution, metabolism, and excretion (eg, bariatric procedure, history of pancreatitis, uncontrolled nausea or vomiting) in the opinion of the investigator.
* Other protocol defined inclusion/exclusion criteria applies.
Interventions
DRUG
Navlimetostat
Conditions
Healthy Participants
Locations
CenExel iResearch - Decatur
Decatur, Georgia 30030
United States
Local Institution - 0003
Decatur, Georgia 30030
United States
Local Institution - 0001
Austin, Texas 78744
United States
Local Institution - 0004
Austin, Texas 78744
United States