NCT07587515PHASE1, PHASE2Recruiting
Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration
Eyconis INC.
Start Date
5/19/2026
Completion Date
5/1/2028
Summary
This Phase 1b/2a study will primarily investigate the safety and tolerability of EYC-0305 delivered by intravitreal (IVT) injection every 24 weeks in patients with neovascular (wet) age-related macular degeneration (AMD). The pharmacokinetics (PK) and immunogenicity of EYC-0305, and the effect on disease activity and vision will also be evaluated.
Eligibility Criteria
Age Range: 50 years to No maximum
Inclusion Criteria:
* Men or women 50 years and older with neovascular (wet) AMD meeting all study-specified eligibility criteria
* Willing and able to comply with clinic visits and study-related procedures
* Provide signed informed consent
Exclusion Criteria:
* Known hypersensitivity or known allergy that would preclude study drug administration
* Inability to obtain ophthalmic imaging, eg, due to media opacity, inadequate pupillary dilation, allergy to fluorescein dye or lack of venous access
* Uncontrolled diabetes mellitus
* History of cerebrovascular accident (CVA) or myocardial infarction within 180 days of the Day 1 visit
* Renal failure, dialysis, or history of renal transplant
* Concurrent psychiatric or medical condition that in the opinion of the Investigator will interfere with study participation or completion
* Pregnant or breastfeeding women
Interventions
BIOLOGICAL
EYC-0305
Conditions
Neovascular (Wet) Age-Related Macular Degeneration
Locations
Beverly Hills, CA
Beverly Hills, California 90211
United States
Wake Forest, NC
Wake Forest, North Carolina 27587
United States
Erie, PA
Erie, Pennsylvania 16505
United States
Bellaire, TX
Bellaire, Texas 77401
United States
McAllen, TX
McAllen, Texas 78503
United States
The Woodlands, TX
The Woodlands, Texas 77384
United States