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NCT07587515PHASE1, PHASE2Recruiting

Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration

Eyconis INC.

Start Date

5/19/2026

Completion Date

5/1/2028

Summary

This Phase 1b/2a study will primarily investigate the safety and tolerability of EYC-0305 delivered by intravitreal (IVT) injection every 24 weeks in patients with neovascular (wet) age-related macular degeneration (AMD). The pharmacokinetics (PK) and immunogenicity of EYC-0305, and the effect on disease activity and vision will also be evaluated.

Eligibility Criteria

Age Range: 50 years to No maximum

Inclusion Criteria: * Men or women 50 years and older with neovascular (wet) AMD meeting all study-specified eligibility criteria * Willing and able to comply with clinic visits and study-related procedures * Provide signed informed consent Exclusion Criteria: * Known hypersensitivity or known allergy that would preclude study drug administration * Inability to obtain ophthalmic imaging, eg, due to media opacity, inadequate pupillary dilation, allergy to fluorescein dye or lack of venous access * Uncontrolled diabetes mellitus * History of cerebrovascular accident (CVA) or myocardial infarction within 180 days of the Day 1 visit * Renal failure, dialysis, or history of renal transplant * Concurrent psychiatric or medical condition that in the opinion of the Investigator will interfere with study participation or completion * Pregnant or breastfeeding women

Interventions

BIOLOGICAL

EYC-0305

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Conditions

Neovascular (Wet) Age-Related Macular Degeneration

Locations

Beverly Hills, CA

Beverly Hills, California 90211

United States

Wake Forest, NC

Wake Forest, North Carolina 27587

United States

Erie, PA

Erie, Pennsylvania 16505

United States

Bellaire, TX

Bellaire, Texas 77401

United States

McAllen, TX

McAllen, Texas 78503

United States

The Woodlands, TX

The Woodlands, Texas 77384

United States