Back to Trials
NCT07589608PHASE2Recruiting

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Eli Lilly and Company

Start Date

5/15/2026

Completion Date

2/1/2028

Summary

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: * See Master Protocol CWMM (NCT06143956) for inclusion criteria Exclusion Criteria: In addition to exclusion criteria in Master Protocol CWMM (NCT06143956): * Have type 1 diabetes or type 2 diabetes * Have an ongoing history of bradyarrhythmia and/or sinus bradycardia * Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm) * Have a history of acute or chronic pancreatitis * All concomitant medications should be at a stable dose for at least 3 months prior to screening

Interventions

DRUG

Macupatide

DRUG

Eloralintide

DRUG

Placebo

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

OverweightObesity

Locations

The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

Chandler, Arizona 85225

United States

Headlands Research - Scottsdale

Scottsdale, Arizona 85260

United States

The Institute for Liver Health II dba Arizona Liver Health-Tucson

Tucson, Arizona 85712

United States

NorCal Medical Research, Inc

Greenbrae, California 94904

United States

Velocity Clinical Research, Huntington Park

Huntington Park, California 90255

United States

Peninsula Research Associates

Rolling Hills Estates, California 90274

United States

Diablo Clinical Research, Inc.

Walnut Creek, California 94598

United States

Stamford Therapeutics Consortium

Stamford, Connecticut 06905

United States

New Horizon Research Center

Miami, Florida 33165

United States

Indago Research & Health Center, Inc

Miami Lakes, Florida 33016

United States

Suncoast Clinical Research, Inc.

New Port Richey, Florida 34652

United States

Charter Research - Winter Park

Orlando, Florida 32803

United States

Charter Research - Lady Lake

The Villages, Florida 32162

United States

Medical Research Partners

Ammon, Idaho 83406

United States

Great Lakes Clinical Trials - Ravenswood

Chicago, Illinois 60640

United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas 66606

United States

Monroe Biomedical Research - Louisville

Louisville, Kentucky 40213

United States

Knownwell

Needham, Massachusetts 02492

United States

Lucida Clinical Trials

New Bedford, Massachusetts 02740

United States

Headlands Research - Detroit

Southfield, Michigan 48034

United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan 48098

United States

StudyMetrix Research

City of Saint Peters, Missouri 63303

United States

Clinvest Headlands Llc

Springfield, Missouri 65807

United States

Las Vegas Medical Research

Las Vegas, Nevada 89128

United States

Dent Neurologic Institute

Amherst, New York 14226

United States

Rochester Clinical Research, LLC

Rochester, New York 14609

United States

Medication Management

Greensboro, North Carolina 27405

United States

Monroe Biomedical Research

Monroe, North Carolina 28112

United States

Lucas Research, Inc

Morehead City, North Carolina 28557

United States

Lucas Research, Inc.

New Bern, North Carolina 28562

United States

CTI Clinical Research Center

Cincinnati, Ohio 45212

United States

Tribe Clinical Research, LLC

Greenville, South Carolina 29607

United States

Quality Medical Research

Nashville, Tennessee 37211

United States

IMA Clinical Research Austin

Austin, Texas 78745

United States

FutureSearch Trials of Dallas

Dallas, Texas 75251

United States

PlanIt Research, PLLC

Houston, Texas 77079

United States

Endeavor Clinical Trials

San Antonio, Texas 78240

United States

Texas Valley Clinical Research

Weslaco, Texas 78596

United States

Sovah Clinical Research-River District

Danville, Virginia 24541

United States

Central Washington Health Services Association d/b/a Confluence Health

Wenatchee, Washington 98801

United States