A Study Evaluating the Prophylactic Use of Tocilizumab to Prevent Cytokine Release Syndrome With Ramantamig Administration in Participants With Relapsed/Refractory Multiple Myeloma
Start Date
6/30/2026
Completion Date
11/8/2030
Summary
The purpose of this study is to find out whether giving a single dose of tocilizumab before treatment with ramantamig can help prevent or reduce the severity of cytokine release syndrome (CRS) within 28 days from ramantamig, compared to participants who receive placebo. CRS is an acute inflammatory reaction that can occur during treatment and may be associated with flu-like or other systemic symptoms, such as fever and tiredness.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Ramantamig
Tocilizumab
Placebo
Conditions
Locations
City of Hope Phoenix
Goodyear, Arizona 85338
United States
Beverly Hills Cancer Center (BHCC)
Beverly Hills, California 90211
United States
City of Hope Orange County Lennar Foundation Cancer Center
Irvine, California 92618
United States
Colorado Blood Cancer Institute
Denver, Colorado 80218
United States
Washington University School Of Medicine
St Louis, Missouri 63110
United States
Hospital Aleman
Buenos Aires, C1118
Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, C1199ABB
Argentina
Instituto Alexander Fleming
Buenos Aires, C1426ANZ
Argentina
Hospital Privado Centro Medico de Cordoba
Córdoba, X5016KEH
Argentina
Concord Repatriation General Hospital
Concord, 2139
Australia
Wollongong Hospital
Wollongong, 2500
Australia
Centre Hospitalier Victor Dupouy
Argenteuil, 95107
France
Centre Hospitalier de la Cote Basque
Bayonne, 64100
France
Centre de Cancerologie de la Sarthe
Le Mans, 72100
France
CHU Nantes - Hotel Dieu
Nantes, 44000
France
Uni General Hospital of Alexandroupolis
Alexandroupoli, 681 00
Greece
251 Air Force General Hospital
Athens, 115 25
Greece
Alexandra General Hospital of Athens
Athens, 11528
Greece
General University Hospital of Patras
Rio, 265 04
Greece
Theageneio Cancer Hospital
Thessaloniki, 546 39
Greece
Hippokration Hospital
Thessaloniki, 54642
Greece
Hospital Ampang
Ampang, 68000
Malaysia
Hospital Pulau Pinang
George Town, 10450
Malaysia
Hospital Sultanah Aminah
Johor Bharu, 80100
Malaysia
Hospital Queen Elizabeth
Kota Kinabalu, 88586
Malaysia
Sarawak General Hospital
Kuching, 93586
Malaysia
Uls Braga - Hosp. Braga
Braga, 4710 243
Portugal
Hosp. Cuf Descobertas
Lisbon, 1998 018
Portugal
Uls Santo Antonio - Hosp. Santo Antonio
Porto, 4050 342
Portugal
Uls Sao Joao - Hosp. Sao Joao
Porto, 4200 319
Portugal
Hosp. Univ. La Paz
Madrid, 28046
Spain
Hosp. de Navarra
Pamplona, 31008
Spain
Hosp. Univ. Dr. Peset
Valencia, 46017
Spain
Falu Lasarett Medicinkliniken Falun
Falun, 791 82
Sweden
Sahlgrenska Universitetssjukhuset
Gothenburg, 413 45
Sweden
Skanes universitetssjukhus
Lund, 221 85
Sweden
Karolinska University Hospital Huddinge
Stockholm, 141 86
Sweden
Akademiska Sjukhuset
Uppsala, 752 37
Sweden