A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine
Start Date
5/28/2026
Completion Date
5/15/2028
Summary
Acute treatments for migraine may not provide sufficient pain relief after an initial dose, and a second dose of a given medication may be needed to fully abort an attack. International Headache Society (IHS) global practice recommendations for the Acute Treatment of Migraine suggest a second dose of the same medication within the recommended dose limit in people with headache relapse after successful initial treatment of a migraine attack. The primary purpose of this study is to evaluate the safety and tolerability of redosing of rimegepant when taken for the acute treatment of a migraine attack, as it is possible that some patients may benefit from a second dose of rimegepant in this setting.
Detailed Description
To evaluate the safety and tolerability of rimegepant 75 mg ODT when redosed due to residual pain or headache relapse
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Rimegepant
Conditions
Locations
Hope Clinical Research
Canoga Park, California 91303
United States
Neurology Offices of South Florida
Boca Raton, Florida 33428
United States
Brainstorm Research
Miami, Florida 33176
United States
Clinical Neuroscience Solutions
Orlando, Florida 32801
United States
New England Regional Headache Center
Worcester, Massachusetts 01609
United States
Michigan Headache & Neurological Institute
Ann Arbor, Michigan 48104
United States
Proven Endpoints, LLC
Ridgeland, Mississippi 39157
United States
Headache Wellness Center
Greensboro, North Carolina 27405
United States
FutureSearch Trials of Neurology
Austin, Texas 78731
United States
FutureSearch Trials of Dallas
Dallas, Texas 75251
United States
MedStar Health - Department of Neurology
McLean, Virginia 22101
United States