A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)
Start Date
6/30/2026
Completion Date
10/12/2027
Summary
Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate). Enlicitide is in a group of medicines that lower the amount of low-density lipoprotein cholesterol (LDL-C). The goals of this trial are to evaluate: * if MK-7262 and enlicitide taken together work better than placebo at lowering Lp(a) and LDL-C levels in the blood * if MK-7262 alone works better than placebo at lowering Lp(a) levels in the blood * the safety and tolerability of taking MK-7262 and enlicitide alone and together
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
MK-7262
Enlicitide
Placebo for MK-7262
Placebo for enlicitide
Conditions
Locations
Advanced Cardiovascular - Alexander City ( Site 0158)
Alexander City, Alabama 35010
United States
AMR Clinical Mobile ( Site 0149)
Mobile, Alabama 36608
United States
National Heart Institute ( Site 0113)
Beverly Hills, California 90211-2285
United States
Headlands Research CTR Lincoln ( Site 0127)
Lincoln, California 95648
United States
Chase Medical Research, LLC ( Site 0163)
Waterbury, Connecticut 06708
United States
Soffer Health Institute ( Site 0123)
Hollywood, Florida 33020
United States
Westside Center for Clinical Research ( Site 0161)
Jacksonville, Florida 32205
United States
Inpatient Research Clinic ( Site 0110)
Miami Lakes, Florida 33014
United States
Clinical Research Trials of Florida ( Site 0101)
Tampa, Florida 33607
United States
Conquest Research LLC ( Site 0140)
Winter Park, Florida 32789
United States
Flourish Research - Bowie ( Site 0106)
Bowie, Maryland 20715
United States
Velocity Clinical Research Rockville ( Site 0146)
Rockville, Maryland 20854
United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0132)
Troy, Michigan 48098
United States
Minneapolis Heart Institute - Minneapolis ( Site 0130)
Minneapolis, Minnesota 55407
United States
Montana Medical Research, Inc. ( Site 0156)
Missoula, Montana 59808
United States
New Mexico Clinical Research & Osteoporosis Center ( Site 0119)
Albuquerque, New Mexico 87106
United States
Laurelton Heart Specialist PC ( Site 0155)
Rosedale, New York 11422
United States
Velocity Clinical Research, Durham ( Site 0145)
Durham, North Carolina 27701
United States
Remington-Davis, Inc. ( Site 0107)
Columbus, Ohio 43215
United States
Holston Medical Group ( Site 0117)
Kingsport, Tennessee 37660
United States
Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0154)
Houston, Texas 77030
United States
DM Clinical Research ( Site 0115)
Tomball, Texas 77375
United States
Carient Heart & Vascular - Manassas ( Site 0165)
Manassas, Virginia 20109
United States
Rainier Clinical Research Center ( Site 0116)
Renton, Washington 98057
United States
North York Diagnostic and Cardiac Centre ( Site 0203)
North York, Ontario M6B 3H7
Canada
Ecogene-21 ( Site 0202)
Chicoutimi, Quebec G7H 7K9
Canada
Clinique des Maladies Lipidiques de Quebec ( Site 0201)
Québec, Quebec G1V 4W2
Canada
Diex Recherche Trois-Rivieres ( Site 0204)
Trois-Rivières, Quebec G9A 4P3
Canada
Salud SURA Industriales ( Site 0405)
Medellín, Antioquia 05001
Colombia
Clinica de la Costa S.A.S ( Site 0404)
Barranquilla, Atlántico 80020
Colombia
Solano & Terront Servicios Medicos - UNIENDO SAS ( Site 0402)
Bogota, Cundinamarca 110221
Colombia
IMAT S.A.S ( Site 0400)
Montería, Departamento de Córdoba 23001
Colombia
Regionshospitalet Viborg ( Site 0507)
Viborg, Central Jutland 8800
Denmark
Sanos Clinic - Nordjylland ( Site 0502)
Gandrup, North Denmark 9362
Denmark
Esbjerg sygehus, Syddansk Universitetshospital ( Site 0505)
Esbjerg, Region Syddanmark 6700
Denmark
OUH Svendborg Sygehus ( Site 0500)
Svendborg, Region Syddanmark 5700
Denmark
Klinikum Konstanz ( Site 0723)
Konstanz, Baden-Wurttemberg 78464
Germany
Deutsches Herzzentrum Muenchen ( Site 0717)
Munich, Bavaria 80636
Germany
Ambulantes Herzzentrum Kassel ( Site 0721)
Kassel, Hesse 34121
Germany
Dedicated Research Site FutureMeds ( Site 0719)
Offenbach, Hesse 63065
Germany
Studienzentrum Brinkum - Torsten Drescher & Dr. Lars Pohlmeier ( Site 0712)
Stuhr, Lower Saxony 28816
Germany
Universitaetsklinikum Carl Gustav Carus, Technische Universitaet Dresden' ( Site 0713)
Dresden, Saxony 01307
Germany
zibp GmbH ( Site 0716)
Berlin, 10439
Germany
FutureMeds GmbH ( Site 0718)
Berlin, 10629
Germany
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 0714)
Berlin, 12203
Germany
Medical Corporation Heishinkai OCROM Clinic ( Site 2403)
Suita, Osaka 565-0853
Japan
Kumanomae Nishimura Naika Clinic ( Site 2407)
Arakawa City, Tokyo 116-0012
Japan
Minamino Cardiovascular Hospital ( Site 2406)
Hachiōji, Tokyo 192-0918
Japan
Kato Clinic of Internal Medicine ( Site 2402)
Katsushika-ku, Tokyo 125-0054
Japan
Swing Nozaki Clinic ( Site 2405)
Musashino, Tokyo 180-0022
Japan
Medical Corporation Heishinkai ToCROM Clinic ( Site 2404)
Shinjuku, Tokyo 160-0008
Japan
Medical Corporation Hakuaikai Wellness Tenjin Clinic ( Site 2400)
Fukuoka, 810-0001
Japan
Midori Clinic ( Site 2401)
Nagasaki, 852-8034
Japan
National Hospital Organization Osaka National Hospital ( Site 2408)
Osaka, 540-0006
Japan
Ziekenhuis Gelderse Vallei ( Site 1106)
Ede, Gelderland 6716 RP
Netherlands
Ziekenhuis St. Jansdal ( Site 1113)
Harderwijk, Gelderland 3844 DG
Netherlands
Bravis Ziekenhuis, locatie Roosendaal ( Site 1102)
Roosendaal, North Brabant 4708 AE
Netherlands
Noordwest Ziekenhuisgroep ( Site 1110)
Alkmaar, North Holland 1815 JD
Netherlands
Antonius Ziekenhuis, locatie D&A Research and Genetics ( Site 1103)
Sneek, Provincie Friesland 8601 ZR
Netherlands
Albert Schweitzer Ziekenhuis, locatie Dordwijk ( Site 1101)
Dordrecht, South Holland 3318 AT
Netherlands
Martini Ziekenhuis ( Site 1108)
Groningen, 9728 NT
Netherlands
Hospital San Rafael - La Coruña ( Site 1402)
A Coruña, La Coruna 15006
Spain
Vithas Hospital Sevilla ( Site 1401)
Castilleja de la Cuesta, Sevilla 41950
Spain
Hospital Universitari Vall d Hebron ( Site 1403)
Barcelona, 08035
Spain
Hospital Clinic de Barcelona ( Site 1419)
Barcelona, 08036
Spain
Hospital Viamed Santa Elena ( Site 1422)
Madrid, 28003
Spain
Hospital Universitario La Paz ( Site 1405)
Madrid, 28046
Spain
Hospital Universitario Virgen de la Arrixaca ( Site 1406)
Murcia, 30120
Spain
Nuevas Tecnologías en D y E - Sevillaocío ( Site 1412)
Seville, 41003
Spain
University Hospital Basel ( Site 1701)
Basel, Canton of Basel-City 4031
Switzerland
HOCH Health Ostschweiz ( Site 1703)
Sankt Gallen, Canton of St. Gallen 9007
Switzerland
Istituto Cardiocentro Ticino - Ente Ospedaliero Cantonale ( Site 1705)
Lugano, Canton Ticino 6900
Switzerland
Hopitaux Universitaires (Geneve) ( Site 1704)
Geneva, 1211
Switzerland
Luzerner Kantonsspital ( Site 1702)
Lucerne, 6000
Switzerland