A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)
Start Date
6/30/2026
Completion Date
10/12/2027
Summary
Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate). Enlicitide is in a group of medicines that lower the amount of low-density lipoprotein cholesterol (LDL-C). The goals of this trial are to evaluate: * if MK-7262 and enlicitide taken together work better than placebo at lowering Lp(a) and LDL-C levels in the blood * if MK-7262 alone works better than placebo at lowering Lp(a) levels in the blood * the safety and tolerability of taking MK-7262 and enlicitide alone and together
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
MK-7262
Enlicitide
Placebo for MK-7262
Placebo for enlicitide
Conditions
Locations
Advanced Cardiovascular - Alexander City ( Site 0158)
Alexander City, Alabama 35010
United States
AMR Clinical Mobile ( Site 0149)
Mobile, Alabama 36608
United States
National Heart Institute ( Site 0113)
Beverly Hills, California 90211-2285
United States
Clinical Trials Research ( Site 0127)
Lincoln, California 95648
United States
Chase Medical Research, LLC ( Site 0163)
Waterbury, Connecticut 06708
United States
Inpatient Research Clinic ( Site 0110)
Miami Lakes, Florida 33014
United States
Clinical Research Trials of Florida ( Site 0101)
Tampa, Florida 33607
United States
Conquest Research LLC ( Site 0140)
Winter Park, Florida 32789
United States
New Mexico Clinical Research & Osteoporosis Center ( Site 0119)
Albuquerque, New Mexico 87106
United States
Remington-Davis, Inc. ( Site 0107)
Columbus, Ohio 43215
United States
Holston Medical Group ( Site 0117)
Kingsport, Tennessee 37660
United States
Carient Heart & Vascular - Manassas ( Site 0165)
Manassas, Virginia 20109
United States