Back to Trials
NCT07620392PHASE2Recruiting

An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

Hoffmann-La Roche

Start Date

6/3/2026

Completion Date

7/8/2033

Summary

The study will evaluate the long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with moderate to severe Rheumatoid Arthritis (RA) who have an inadequate response or intolerance to tumor necrosis factor (TNF) and/or Janus kinase (JAK) inhibitors, and who were previously treated with Afimkibart.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Completed the treatment period of the parent study * Agreement to adhere to the contraception requirements * Continued to be evaluated at the follow-up visit of the parent study and achieved improvement in the SJC66/TJC68 relative to baseline Exclusion Criteria: * Withdrawal of consent and/or premature discontinuation from parent study * Any permanent discontinuation of study drug in parent study * Use of a prohibited therapy during the parent study * Evidence of any new or uncontrolled concomitant disease that, in the investigator's judgment, would preclude participant participation in the trial

Interventions

DRUG

Afimkibart

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Rheumatoid Arthritis

Locations

West Broward Rheumatology Associates, Inc.

Tamarac, Florida 33321

United States

Accurate Clinical Management LLC

Houston, Texas 77089

United States

DM Clinical Research

Tomball, Texas 77375

United States

Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spó?ka Partne

Elblag, 82-300

Poland

Zespol Poradni Specjalistycznych REUMED filia nr 1 Wallenroda

Lublin, 20-607

Poland

Reumatop Grzegorz Rozumek Karin Pistorius Spolka Jawna

Wroclaw, 52-210

Poland