NCT07638748NARecruiting

Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment

The University of Texas Health Science Center, Houston

Start Date

6/18/2026

Completion Date

11/13/2026

Summary

The purpose of this study is to demonstrate feasibility, usability, and acceptability of virtual reality (VR)-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognitive, physical, and functional outcomes.

Eligibility Criteria

Age Range: 55 years to 90 years

Inclusion Criteria: * Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD) * Capacity to provide informed consent * Able to provide own transportation to sessions * Speaks and understands English * Ambulatory Exclusion Criteria: * Uncontrolled seizures or epilepsy * Severe psychiatric illness or active suicidality * Inability to follow instructions or tolerate VR (severe motion sickness) * Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.) * Any condition that the research team determines would interfere with safe participation

Interventions

DEVICE

Virtual Reality (VR) sessions

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Conditions

Mild Cognitive ImpairmentSubjective Cognitive Decline (SCD)

Locations

The University of Texas Health Science Center at Houston

Houston, Texas 77030

United States