NCT07715188NARecruiting
Low Dose Radiotherapy for Osteoarthritis
Abramson Cancer Center at Penn Medicine
Start Date
6/24/2026
Completion Date
6/1/2029
Summary
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Detailed Description
To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* 18 years or older
* Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows.
* Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
* Provision of signed and dated informed consent.
Exclusion Criteria:
* Unable to reasonably complete study instruments.
Interventions
RADIATION
Low Dose Radiation Therapy
Conditions
Osteoarthitis
Locations
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania 19104
United States
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania 19104
United States