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NCT07804446NARecruiting

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

University of Chicago

Start Date

8/31/2026

Completion Date

5/1/2027

Summary

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Eligibility Criteria

Age Range: 40 years to No maximum

Inclusion Criteria: * Age ≥ 40 * Clinical diagnosis of knee OA with predominant medial compartment symptoms * Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent) * Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee * Able to provide informed consent * Able to complete phone, email, or MyChart follow-ups in English Exclusion Criteria: * Predominant lateral compartment OA or patellofemoral-only OA * Inflammatory arthritis (RA, gout flare, etc.) * Suspected or confirmed joint infection or overlying cellulitis * Prior knee arthroplasty on the index knee * Planned surgery for index knee within 12-week follow-up * Inability to complete follow-up assessments * Other clinician-determined contraindication to CSI

Interventions

PROCEDURE

Anteromedial Injection

PROCEDURE

Anterolateral Injection

Interested in This Trial?

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Conditions

OsteoarthitisOsteoarthritic Knee PainOsteoarthritis (OA)Osteoarthritis (OA) of the KneeOsteoarthritis in the Knee

Locations

Bolingbrook Clinic

Bolingbrook, Illinois 60440

United States

Hyde Park Clinic

Chicago, Illinois 60637

United States

La Grange Clinic

La Grange, Illinois 60525

United States

Orland Park Clinic

Orland Park, Illinois 60462

United States

Woodridge Clinic

Woodridge, Illinois 60517

United States