NCT07804446NARecruiting
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
University of Chicago
Start Date
8/31/2026
Completion Date
5/1/2027
Summary
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Eligibility Criteria
Age Range: 40 years to No maximum
Inclusion Criteria:
* Age ≥ 40
* Clinical diagnosis of knee OA with predominant medial compartment symptoms
* Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
* Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
* Able to provide informed consent
* Able to complete phone, email, or MyChart follow-ups in English
Exclusion Criteria:
* Predominant lateral compartment OA or patellofemoral-only OA
* Inflammatory arthritis (RA, gout flare, etc.)
* Suspected or confirmed joint infection or overlying cellulitis
* Prior knee arthroplasty on the index knee
* Planned surgery for index knee within 12-week follow-up
* Inability to complete follow-up assessments
* Other clinician-determined contraindication to CSI
Interventions
PROCEDURE
Anteromedial Injection
PROCEDURE
Anterolateral Injection
Conditions
OsteoarthitisOsteoarthritic Knee PainOsteoarthritis (OA)Osteoarthritis (OA) of the KneeOsteoarthritis in the Knee
Locations
Bolingbrook Clinic
Bolingbrook, Illinois 60440
United States
Hyde Park Clinic
Chicago, Illinois 60637
United States
La Grange Clinic
La Grange, Illinois 60525
United States
Orland Park Clinic
Orland Park, Illinois 60462
United States
Woodridge Clinic
Woodridge, Illinois 60517
United States