NCT07738614PHASE1RecruitingAccepts Healthy Volunteers
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight
Eli Lilly and Company
Start Date
7/31/2026
Completion Date
12/1/2026
Summary
The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 and 8 days. There will be 13 other visits.
Eligibility Criteria
Age Range: 18 years to 65 years
Inclusion Criteria:
* Have overweight or obesity, but are otherwise overtly healthy.
* Have a body mass index (BMI) within the range of 27.0 to 45.0 kilograms (kg)/square meter (m²), inclusive.
* Have had a stable body weight, with less than 5 percent (%) change during the 3-month period prior to screening.
Exclusion Criteria:
* Have been diagnosed with Type 1 or Type 2 diabetes mellitus, or have either of the following at screening
* A fasting plasma glucose concentration greater than or equal to 126 milligrams (mg)/deciliter (dL) or 7.0 millimoles (mmol)/liter (L), or
* Hemoglobin A1C (HbA1c) greater than or equal to 6.5% or 48 mmol/mole (mol).
* Have a history or presence of psychiatric disorders, including a history of major depressive disorder or severe psychiatric disorders such as schizophrenia, and bipolar disorder, within the last 2 years.
* Have received a glucagon-like peptide-1 (GLP-1) receptor agonist, glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist, or GIP/GLP-1/glucagon receptor agonist within 60 days or 5 half-lives, whichever is longer, prior to screening.
* Are in the judgment of the investigator, actively suicidal or deemed to be at significant risk for suicide.
Interventions
DRUG
Eloralintide
DRUG
Placebo
DRUG
Acetaminophen
Conditions
ObesityOverweight
Locations
ICON Early Phase Services
San Antonio, Texas 78209
United States
Lilly Centre for Clinical Pharmacology
Singapore, 138623
Singapore