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NCT07743476Recruiting

Bone Marrow Imaging and Clinical Outcomes Across Hematologic, Oncologic, and Other Relevant Conditions

M.D. Anderson Cancer Center

Start Date

8/31/2026

Completion Date

12/31/2038

Summary

An observational study of patients with hematologic, oncologic, and other relevant conditions undergoing bone marrow imaging, with longitudinal collection of imaging, treatment, and clinical outcome data to characterize bone marrow features and changes over time

Detailed Description

Primary Objective To establish a longitudinal cohort integrating bone marrow imaging with clinical and treatment-related data. Primary Endpoint Successful enrollment of eligible participants and collection of relevant imaging and clinical data. Secondary Objective * Characterize bone marrow imaging findings across relevant patient populations. * Evaluate relationships between imaging findings, treatment exposures, hematologic recovery, treatment-related toxicities, and clinical outcomes. * Assess longitudinal changes in bone marrow imaging findings over time and following cancer therapy. * Explore associations between imaging findings and laboratory, pathology, and research biomarker data when available.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria * Diagnosis of a hematologic, oncologic, or other condition relevant to the study. * Availability of clinical, imaging, laboratory, treatment, and/or outcome data relevant to the study. * Ability to provide informed consent for prospective participation or, for pediatric participants, parent/legal guardian permission with assent when applicable. * Participants undergoing research MRI must be eligible for MRI according to institutional safety requirements. Exclusion Criteria * Inability to provide required informed consent or parental/legal guardian permission for prospective participation. * Insufficient clinical information to support study participation * Pregnancy. * Contraindication to MRI will exclude participants from research-specific MRI but not necessarily from other study components.

Interventions

OTHER

Data Collection

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Conditions

HematologicOncologicBone Marrow

Locations

UT MD Anderson Cancer Center

Houston, Texas 77030

United States