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NCT07766720NARecruitingAccepts Healthy Volunteers

Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise

ESM Technologies, LLC

Start Date

2/1/2026

Completion Date

12/31/2026

Summary

Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients affects recovery from intense exercise.

Detailed Description

Eggshell membrane (EM) is derived from the inner fibrous layer of eggs that contain a number of proteins and Types I, V, and X collagen and sulfur containing amino acids (i.e., e.g., methionine, cysteine), glycosaminoglycans (e.g., hyaluronic acid, dermatan sulfate, chondroitin sulfate) that are found in synovium, cartilage, ligaments, and tendons of human joint tissue. Initial studies have shown that EM supplementation reduces inflammation and perception of pain while improving markers of joint health in individuals with osteoarthritis. Curcumin (Curcuma longa) is a member of the ginger family (Zingiberaceae) that contains polyphenols that have anti-inflammatory properties. Studies show that curcumin (Curc) can reduce inflammation related to osteoarthritis, exercise, concussion and traumatic brain injury. Theoretically, EM and Curc supplementation prior to intense exercise may reduce inflammation, perceptions of muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients (NEM® brand eggshell membrane and curQ+® brand highly absorbable curcumin) separately and in combination affects recovery from intense exercise in recreationally active men.

Eligibility Criteria

Age Range: 18 years to 40 years

Inclusion Criteria: * Age 18 to 40 at the time of consent. * Healthy and recreationally active. * Ability to comply with study procedures. * Agree to refrain from alcohol intake and use of non-steroidal anti-inflammatory (NSAIDS), aspirin, and other over-the-counter pain medications for 48 hours prior to and after completion of each testing session. Exclusion Criteria: * No recent history of exercise training * An orthopedic limitation that would prevent the ability to perform the exercise intervention. * Participants who currently smoke cigarettes. * Known allergies to eggs, sulfur, or curcumin.

Interventions

DIETARY_SUPPLEMENT

NEM® brand eggshell membrane powder

DIETARY_SUPPLEMENT

curQ+® brand highly absorbable curcumin

DIETARY_SUPPLEMENT

EM Placebo

DIETARY_SUPPLEMENT

Curc Placebo

DIETARY_SUPPLEMENT

NEM® plus curQ+® combination

Interested in This Trial?

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Conditions

Exercise-induced Muscle SorenessExercise-induced Joint PainExercise-induced Joint StiffnessExercise-induced Cartilage Turnover

Locations

Exercise & Sport Nutrition Lab - Texas A&M University

College Station, Texas 77843

United States