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NCT07786207Recruiting

Knee Cartilage Repair Registry

Smith & Nephew, Inc.

Start Date

9/23/2026

Completion Date

3/31/2034

Summary

This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage. Information will be collected from patients undergoing knee surgery for cartilage damage and entered into a large database that reflects routine clinical practice ("real-world" data). The data collected will be used to support future research and improve understanding of treatment outcomes for knee cartilage repair.

Detailed Description

The registry will collect both prospective and retrospective/prospective data.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: Prospective Subjects * Provides written informed consent. * Is eighteen (18) years of age or older at time of consent and considered skeletally mature in the opinion of the investigator. * Scheduled to undergo knee cartilage surgery with the Marketed Product-MP01 OR other knee cartilage repair surgery. * For subjects having other knee cartilage repair surgery: \- Falls within Marketed Product-MP01 on label indication: Knee chondral or osteochondral lesions (ICRS grade III and above, 1-7cm2) in patients with or without mild-moderate knee osteoarthritis (K/L 0-3). * Has an electronic device and is willing and able to use the device to complete the 'Electronic Clinical Outcomes Assessment' (eCOA). * Willing and able to complete all requested questionnaires. * Able to follow instructions and deemed capable of completing registry protocol requirements. Retrospective/Prospective Subjects * Provides written informed consent. * Was eighteen (18) years of age or older at time of surgery and considered skeletally mature at that time in the opinion of the investigator. * Underwent knee cartilage repair surgery with the Marketed Product-MP01 within the last 2-years. * Has an electronic device and is willing and able to use the device to complete the eCOA. * Willing and able to complete all requested questionnaires. * Able to follow instructions and deemed capable of completing registry protocol requirements. * Consents to retrospective data being collected from pre-operative visit(s) and surgery through to the point of consent as available in their medical notes. Exclusion Criteria: * History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate/coral derivatives. * Is actively participating in a cartilage repair clinical trial. * For subjects having other knee cartilage repair surgery: \- Treatment will be on patellar lesion(s). * Has participated previously in this registry (with the index or contralateral knee). * Meets the definition of a Vulnerable Subject per ISO 14155 Section 3.56.

Interventions

DEVICE

Marketed Product - MP01

PROCEDURE

Other Surgical Treatments

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

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Conditions

Knee InjuriesJoint Surface Knee Lesions

Locations

Orthopedic Centers of Colorado

Parker, Colorado 80134

United States

CAO Research Foundation

Washington D.C., District of Columbia 20036

United States

The Orthopaedic Research Foundation, Inc.

Indianapolis, Indiana 46278

United States

Western Kentucky Heart and Lung Research Foundation

Bowling Green, Kentucky 42101

United States

The Physician's Group, LLC

Oklahoma City, Oklahoma 73114

United States

Penn Highlands DuBois

DuBois, Pennsylvania 15801

United States