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NCT07817251PHASE3Recruiting

Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema

Novo Nordisk A/S

Start Date

9/16/2026

Completion Date

7/21/2027

Summary

The purpose of this clinical study is to look at the safety and tolerability of switching from semaglutide to CagriSema, for participants who have type 2 diabetes. All participants will get CagriSema, the treatment being tested. Participants will be in this clinical study for about 6 months.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18 years or above at the time of signing the informed consent. * Diagnosed with type 2 diabetes mellitus (T2DM) greater than or equal to (≥) 180 days before screening. * Stable once-weekly dose ≥ 90 days before screening of branded s.c. semaglutide. Branded semaglutide s.c. includes Ozempic and Wegovy. Participants on compounded semaglutide are ineligible. * Not on treatment with oral antidiabetic drugs or on stable daily dose(s) ≥ 90 days before screening of any of the following antidiabetic drug(s) or combination regimen at effective or maximum tolerated dose (MTD) as judged by the investigator: metformin and/or sodiumglucose co-transporter-2 (SGLT2) inhibitor. * Glycated haemoglobin (HbA1c) 6.5-10.5 percentage (%) (48-91 millimoles per mole \[mmol/mol\]) (both inclusive) as determined by central laboratory at screening. * Body mass index (BMI) ≥ 25 kilograms per square meter (kg/m\^2) at screening. BMI will be calculated in the electronic case report form (eCRF) based on height and body weight at screening. Exclusion criteria: * Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using a highly effective contraceptive method from screening. * Renal impairment with estimated glomerular filtration rate (eGFR) less than (\<) 30 milliliter per minute per 1.73 square meter (mL/min/1.73 m\^2) as determined by central laboratory at screening. * Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. * Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * A self-reported change in body weight \> 5% within 90 days before screening irrespective of medical records. * Use of personal continuous glucose monitoring (CGM) devices. Participants currently using personal CGM devices must discontinue use prior to screening and throughout study participation.

Interventions

DRUG

CagriSema

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Conditions

Diabetes Mellitus, Type 2

Locations

Gilbert Center For Family Medicine

Gilbert, Arizona 85296

United States

Ark Clinical Research

Fountain Valley, California 92708

United States

Thrive Clinical Research Group

Glendora, California 91740

United States

Scripps Whittier Diabetes Inst

La Jolla, California 92037

United States

Downtown LA Res Ctr. Inc.

Los Angeles, California 90017

United States

Valley Clinical Trials, Inc.

Northridge, California 91325

United States

Dream Team Clinical Research

Pomona, California 91767

United States

Clinical Trials Research_Sacramento

Sacramento, California 95821

United States

Linda Vista Health Care Ctr

San Diego, California 92111

United States

Chase Medical Research LLC

Waterbury, Connecticut 06708

United States

Northeast Research Institute

Fleming Island, Florida 32003

United States

AGA Clinical Trial

Hialeah, Florida 33012

United States

Adult Medicine of Lake County, Inc

Mt. Dora, Florida 32757

United States

Optimal Research Sites

Orange City, Florida 32763

United States

Metabolic Research Institute Inc

West Palm Beach, Florida 33401

United States

East West Med Res Inst

Honolulu, Hawaii 96814

United States

Endeavor Health

Skokie, Illinois 60077

United States

Iowa Diabetes & Endo Res Ctr

West Des Moines, Iowa 50266

United States

Alliance for Multispecialty Research

Newton, Kansas 67114

United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas 66606

United States

Northern Pines Hlth Ctr, PC

Buckley, Michigan 49620

United States

Palm Research Center Inc-Vegas

Las Vegas, Nevada 89128

United States

Albuquerque Clinical Trials Inc.

Albuquerque, New Mexico 87102

United States

PharmQuest Life Sciences LLC

Greensboro, North Carolina 27408

United States

Accellacare Wilmington

Wilmington, North Carolina 28401

United States

Advanced Medical Research

Maumee, Ohio 43537

United States

Clinical Research Associates

Nashville, Tennessee 37203

United States

Amarillo Med Spec LLP

Amarillo, Texas 79124

United States

Texas Diabetes & Endocrinology

Austin, Texas 78749

United States

North Texas Endocrine Center

Dallas, Texas 75231

United States

Diabetes and Thyroid Center of Fort Worth

Fort Worth, Texas 76132

United States

JCCT- Juno NW Houston

Houston, Texas 77040

United States

Sante Clinical Research

Kerrville, Texas 78028

United States

DCOL Ctr for Clin Res

Longview, Texas 75605

United States

North Hills Medical Research Inc

North Richland Hills, Texas 76180

United States

NE Clin Res of San Antonio

San Antonio, Texas 78233

United States

J.Lewis Research Inc

Salt Lake City, Utah 84109

United States

Diabetes & Endo Treatment Spec

Sandy City, Utah 84093

United States

Chrysalis Clinical Research

St. George, Utah 84790

United States

Tidewater Physicians Multispecialty Group

Newport News, Virginia 23606

United States