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NCT07841470PHASE2, PHASE3Recruiting

Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia

Price Vision Group

Start Date

10/1/2025

Completion Date

6/30/2031

Summary

This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.

Detailed Description

Subjects diagnosed with keratoconus or corneal ectasia are randomized to one of two corneal crosslinking light durations.

Eligibility Criteria

Age Range: 10 years to 90 years

Inclusion Criteria: * Diagnosis of keratoconus or corneal ectasia * Provision of written informed consent Exclusion Criteria: * Previous ocular condition in the study eye that may predispose for future complications including history of corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, corneal melt, corneal dystrophy, etc.) * Clinically significant corneal scarring in the proposed treatment zone * History of chemical injury or delayed epithelial healing in the study eye * Known sensitivity to study medication * A current condition, including clinically significant dry eyes or use of medications know to induce dry eye symptoms, that, in the treating physician's opinion, would interfere with or prolong epithelial healing * Pregnancy (including plan to become pregnant) or lactation during the course of the study

Interventions

COMBINATION_PRODUCT

Riboflavin 0.1% ophthalmic solution and pulsed light

COMBINATION_PRODUCT

Riboflavin 0.1% ophthalmic solution and non-pulsed light

Interested in This Trial?

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Conditions

KeratoconusCorneal Ectasia

Locations

Price Vision Group

Indianapolis, Indiana 46260

United States