NCT07841470PHASE2, PHASE3Recruiting
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
Price Vision Group
Start Date
10/1/2025
Completion Date
6/30/2031
Summary
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
Detailed Description
Subjects diagnosed with keratoconus or corneal ectasia are randomized to one of two corneal crosslinking light durations.
Eligibility Criteria
Age Range: 10 years to 90 years
Inclusion Criteria:
* Diagnosis of keratoconus or corneal ectasia
* Provision of written informed consent
Exclusion Criteria:
* Previous ocular condition in the study eye that may predispose for future complications including history of corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, corneal melt, corneal dystrophy, etc.)
* Clinically significant corneal scarring in the proposed treatment zone
* History of chemical injury or delayed epithelial healing in the study eye
* Known sensitivity to study medication
* A current condition, including clinically significant dry eyes or use of medications know to induce dry eye symptoms, that, in the treating physician's opinion, would interfere with or prolong epithelial healing
* Pregnancy (including plan to become pregnant) or lactation during the course of the study
Interventions
COMBINATION_PRODUCT
Riboflavin 0.1% ophthalmic solution and pulsed light
COMBINATION_PRODUCT
Riboflavin 0.1% ophthalmic solution and non-pulsed light
Conditions
KeratoconusCorneal Ectasia
Locations
Price Vision Group
Indianapolis, Indiana 46260
United States