Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer
Start Date
9/16/2026
Completion Date
8/17/2033
Summary
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with Homologous Recombination Deficient (HRD) negative advanced ovarian cancer.
Detailed Description
This study aims to see if torvu-sam in combination with bevacizumab allows patients to live longer without the cancer getting worse, compared to patients receiving bevacizumab. Eligible patients will be those patients who have not progressed following completion of first line induction treatment with Platinum-based chemotherapy (PBC) and bevacizumab. All patients must be HRD-negative through pre-existing study approved local test or prospective central test and have a confirmed folate receptor alpha status determined by prospective central test.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Torvutatug samrotecan
Bevacizumab
Conditions
Locations
Research Site
Tampa, Florida 33606
United States
Research Site
Baltimore, Maryland 21201
United States
Research Site
Billings, Montana 59106
United States
Research Site
Cleveland, Ohio 44195
United States
Research Site
Buenos Aires, C1122AAL
Argentina
Research Site
Buenos Aires, C1125ABD
Argentina
Research Site
Capital Federal, 1118
Argentina
Research Site
Ciudad de Buenos Aires, 1015
Argentina
Research Site
Ciudad de Buenos Aires, 1426
Argentina
Research Site
Córdoba, X5000AAW
Argentina
Research Site
Córdoba, X5000HXK
Argentina
Research Site
Córdoba, X5008HHW
Argentina
Research Site
Rosario, S2000KZE
Argentina
Research Site
Salta, A4400EMI
Argentina
Research Site
Santa Fe, S2002RE
Argentina
Research Site
Viedma, R8500ACE
Argentina
Research Site
Auchenflower, 4066
Australia
Research Site
Benowa, 4217
Australia
Research Site
Hobart, 7000
Australia
Research Site
Kingswood, 2747
Australia
Research Site
Nedlands, 6009
Australia
Research Site
Port Macquarie, 2444
Australia
Research Site
Randwick, 2031
Australia
Research Site
Richmond, 3121
Australia
Research Site
Toorak Gardens, 5065
Australia
Research Site
Wollongong, 2500
Australia
Research Site
Fortaleza, 60336-045
Brazil
Research Site
Itajaí, 88301-220
Brazil
Research Site
Jaú, 17210-080
Brazil
Research Site
Natal, 59075-740
Brazil
Research Site
Porto Alegre, 90020-090
Brazil
Research Site
Rio de Janeiro, 20230-130
Brazil
Research Site
Salvador, 41253-190
Brazil
Research Site
São Paulo, 01317-000
Brazil
Research Site
São Paulo, 01409-902
Brazil
Research Site
São Paulo, 04014-002
Brazil
Research Site
Dobrich, 9300
Bulgaria
Research Site
Plovdiv, 4000
Bulgaria
Research Site
Shumen, 9700
Bulgaria
Research Site
Sofia, 1330
Bulgaria
Research Site
Sofia, 1407
Bulgaria
Research Site
Sofia, 1797
Bulgaria
Research Site
Toronto, Ontario M5G 2M9
Canada
Research Site
Montreal, Quebec H4A 3J1
Canada
Research Site
Santiago, 7520426
Chile
Research Site
Santiago,
Chile
Research Site
Temuco, 4780000
Chile
Research Site
Viña del Mar, 2540364
Chile
Research Site
Beijing, 100034
China
Research Site
Beijing, 100036
China
Research Site
Beijing, 100210
China
Research Site
Beijing, 100730
China
Research Site
Binzhou Shi, 256603
China
Research Site
Changchun, 130021
China
Research Site
Changsha, 410013
China
Research Site
Chengdu, 610072
China
Research Site
Chongqing, 400030
China
Research Site
Fuzhou, 350014
China
Research Site
Guangzhou, 510080
China
Research Site
Haikou, 570311
China
Research Site
Hangzhou, 310003
China
Research Site
Hangzhou, 310022
China
Research Site
Hangzhou, 310052
China
Research Site
Hefei, 230031
China
Research Site
Huangpu District, 200025
China
Research Site
Jinan, 250021
China
Research Site
Jinan, 250117
China
Research Site
Linyi, 276001
China
Research Site
Luzhou, 646000
China
Research Site
Nanchang, 330006
China
Research Site
Nanjing, 210000
China
Research Site
Nanjing, 210009
China
Research Site
Neijiang, 641000
China
Research Site
Shanghai, 200011
China
Research Site
Shanghai, 200032
China
Research Site
Shenzhen, 518039
China
Research Site
Shijiazhuang, 050000
China
Research Site
Suzhou, 215004
China
Research Site
Taiyuan, 030013
China
Research Site
Weifang, 261000
China
Research Site
Wenzhou, 325015
China
Research Site
Wuhan, 430060
China
Research Site
Xinxiang, 453100
China
Research Site
Xuzhou, 221009
China
Research Site
Bogotá, 110221
Colombia
Research Site
Bogotá,
Colombia
Research Site
Medellín, 50018
Colombia
Research Site
Pasto, 520002
Colombia
Research Site
Berlin, 13353
Germany
Research Site
Bonn, 53127
Germany
Research Site
Hanover, 30625
Germany
Research Site
Wiesbaden, 65199
Germany
Research Site
Athens, 11528
Greece
Research Site
Pátrai, 26332
Greece
Research Site
Ansārinagar, 110 029
India
Research Site
Bhubaneswar, 751007
India
Research Site
Hyderabad, 500004
India
Research Site
Mumbai, 400012
India
Research Site
Mumbai, 400016
India
Research Site
Nagpur, 440001
India
Research Site
Nashik, 422 009
India
Research Site
New Delhi, 110 085
India
Research Site
Pune, 411004
India
Research Site
Thiruvananthapuram, 695011
India
Research Site
Hadera, 38100
Israel
Research Site
Haifa, 31096
Israel
Research Site
Haifa, 34362
Israel
Research Site
Holon, 5822012
Israel
Research Site
Jerusalem, 9103102
Israel
Research Site
Kfar Saba, 44281
Israel
Research Site
Nahariya, 22100
Israel
Research Site
Tel Aviv, 6423906
Israel
Research Site
Florence, 50134
Italy
Research Site
Genova, 16132
Italy
Research Site
Fukushima, 960-1295
Japan
Research Site
Ginowan-shi, 901-2725
Japan
Research Site
Hidaka-shi, 350-1298
Japan
Research Site
Isehara-shi, 259-1193
Japan
Research Site
Kashiwa-shi, 277-8567
Japan
Research Site
Kawasaki-shi, 216-8511
Japan
Research Site
Kobe, 650-0047
Japan
Research Site
Kōtoku, 135-8550
Japan
Research Site
Kurume-shi, 830-0011
Japan
Research Site
Kyoto, 612-8555
Japan
Research Site
Minatoku, 105-8471
Japan
Research Site
Nagoya, 464-8681
Japan
Research Site
Nagoya, 466-8560
Japan
Research Site
Niigata, 951-8520
Japan
Research Site
Osaka, 541-8567
Japan
Research Site
Osaka, 545-8586
Japan
Research Site
Ota-shi, 373-8550
Japan
Research Site
Sagamihara-shi, 252-0375
Japan
Research Site
Sapporo, 003-0804
Japan
Research Site
Sapporo, 060-8543
Japan
Research Site
Sendai, 980-8574
Japan
Research Site
Shinjuku-ku, 160-8582
Japan
Research Site
Shiwa-gun, 028-3695
Japan
Research Site
Suita, 565-0871
Japan
Research Site
Sunto-gun, 411-8777
Japan
Research Site
Toon-Shi, 791-0295
Japan
Research Site
Tsu, 514-8507
Japan
Research Site
Yokohama, 236-0004
Japan
Research Site
Yokohama, 241-8515
Japan
Research Site
Kuala Lumpur, 59100
Malaysia
Research Site
Kuala Selangor, 46050
Malaysia
Research Site
Kuala Selangor, 62250
Malaysia
Research Site
Petaling Jaya, 46300
Malaysia
Research Site
Arequipa, AREQUIPA01
Peru
Research Site
Lima, 15036
Peru
Research Site
Lima, 15038
Peru
Research Site
Lima, LIMA 32
Peru
Research Site
Wanchac, 8002
Peru
Research Site
Cebu, 6000
Philippines
Research Site
City of Muntinlupa, 1780
Philippines
Research Site
Quezon, 1102
Philippines
Research Site
Trenčín, 81171
Slovakia
Research Site
Ljubljana, 1000
Slovenia
Research Site
Busan, 49241
South Korea
Research Site
Daegu, 42601
South Korea
Research Site
Goyang-si, 10408
South Korea
Research Site
Gyeonggi-do, 13620
South Korea
Research Site
Seongnam-si, 13496
South Korea
Research Site
Seoul, 03080
South Korea
Research Site
Seoul, 03722
South Korea
Research Site
Seoul, 06273
South Korea
Research Site
Seoul, 06351
South Korea
Research Site
Seoul, 06591
South Korea
Research Site
Seoul, 5505
South Korea
Research Site
Yangsan, 50612
South Korea
Research Site
Barcelona, 08003
Spain
Research Site
Barcelona, 08025
Spain
Research Site
Kaohsiung City, 81362
Taiwan
Research Site
Kaohsiung City, 833401
Taiwan
Research Site
New Taipei City, 220
Taiwan
Research Site
Taichung, 40447
Taiwan
Research Site
Taichung, 40705
Taiwan
Research Site
Tainan, 70403
Taiwan
Research Site
Tainan, 73657
Taiwan
Research Site
Taipei, 100
Taiwan
Research Site
Taipei, 10449
Taiwan
Research Site
Taipei, 11217
Taiwan
Research Site
Taipei, 11259
Taiwan
Research Site
Taoyuan, 333
Taiwan
Research Site
Bangkok, 10210
Thailand
Research Site
Bangkok, 10300
Thailand
Research Site
Bangkok, 10330
Thailand