A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Start Date
11/21/2025
Completion Date
2/1/2030
Summary
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess the safety and efficacy of neoadjuvant carboplatin and mirvetuximab soravtansine in participants with folate receptor alpha (FRα) -expressing advanced-stage serous epithelial ovarian, fallopian tube or primary peritoneal cancer (EOC). Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by delivering a cell-killing drug to cancer cells carrying a protein called folate receptor alpha (FRα). This is a single arm study in adult participants with advanced-stage Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) III-IV FRα-expressing serous EOC. Around 140 participants will be enrolled in the study at approximately 80 sites in the United States. Participants will receive intravenous infusion of MIRV in combination with carboplatin on day 1 of each cycle, every 21 days for up to 6 - 9 Cycles. The total study duration will be approximately 3 years . There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Carboplatin
Mirvetuximab Soravtansine
Bevacizumab
Conditions
Locations
University of Alabama at Birmingham (UAB) Hospital /ID# 274793
Birmingham, Alabama 35294
United States
Usa Mitchell Cancer Institute /ID# 276022
Mobile, Alabama 36604
United States
University of California Los Angeles Medical Center /ID# 274566
Los Angeles, California 90095
United States
Scripps Md Anderson - Prebys Cancer Center /ID# 276891
San Diego, California 92103
United States
California Pacific Medical Center - Van Ness Campus /ID# 275329
San Francisco, California 94109
United States
Ridley Tree Cancer Center /ID# 275219
Santa Barbara, California 93105
United States
Danbury Hospital, Western Connecticut Health Network /ID# 274783
Danbury, Connecticut 06810
United States
Yale University School of Medicine /ID# 275794
New Haven, Connecticut 06510
United States
Norwalk Hospital /ID# 274561
Norwalk, Connecticut 06856
United States
Jupiter Medical Center /ID# 276616
Jupiter, Florida 33458
United States
Mount Sinai Medical Center /ID# 274868
Miami Beach, Florida 33140
United States
Rush Md Anderson Cancer Center /ID# 274926
Chicago, Illinois 60607
United States
OSF St. Francis Medical Center /ID# 274752
Peoria, Illinois 61637-0001
United States
Carle Foundation Hospital /ID# 276470
Urbana, Illinois 61801
United States
Parkview Research Center /ID# 274338
Fort Wayne, Indiana 46845
United States
Indiana University Melvin and Bren Simon Cancer Center /ID# 275492
Indianapolis, Indiana 46202
United States
Baptist Health Lexington /ID# 275218
Lexington, Kentucky 40503
United States
Norton Cancer Institute - St. Matthews /ID# 276173
Louisville, Kentucky 40207
United States
Women'S Cancer Care /ID# 276469
Covington, Louisiana 70433
United States
University Medical Center New Orleans /ID# 274755
New Orleans, Louisiana 70112
United States
Trials 365 /ID# 274310
Shreveport, Louisiana 71103
United States
University of Maryland, Baltimore /ID# 275308
Baltimore, Maryland 21201
United States
Holy Cross Hospital /ID# 275872
Silver Spring, Maryland 20910
United States
University of Minnesota - Minneapolis /ID# 275718
Minneapolis, Minnesota 55455-0341
United States
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 274780
Saint Louis Park, Minnesota 55416
United States
University Of Mississippi Medical Center /ID# 276342
Jackson, Mississippi 39216
United States
Cox Medical Center South /ID# 274826
Springfield, Missouri 65807
United States
Mercy David C. Pratt Cancer Center /ID# 275655
St Louis, Missouri 63141
United States
The Center Of Hope /ID# 274313
Reno, Nevada 89511
United States
Dartmouth-Hitchcock Medical Center /ID# 274676
Lebanon, New Hampshire 03756
United States
John Theurer Cancer Center /ID# 275756
Hackensack, New Jersey 07601
United States
Rutgers Cancer Institute of New Jersey /ID# 274358
New Brunswick, New Jersey 08901
United States
Holy Name Medical Center /ID# 276240
Teaneck, New Jersey 07666
United States
Optimum Clinical Research Group /ID# 274583
Albuquerque, New Mexico 87109
United States
Imbert Cancer Center /ID# 275634
Bay Shore, New York 11706
United States
Northwell Health Cancer Institute At Huntington /ID# 276814
Greenlawn, New York 11740
United States
Northwell Health Center for Advanced Medicine. /ID# 275641
Lake Success, New York 11042
United States
Northwell Health Queens Cancer Center /ID# 274850
Rego Park, New York 11374
United States
University of North Carolina Medical Center /ID# 275307
Chapel Hill, North Carolina 27514
United States
Atrium Health Levine Cancer Institute /ID# 274557
Charlotte, North Carolina 28204
United States
East Carolina University - Brody School of Medicine /ID# 275770
Greenville, North Carolina 27834
United States
Atrium Health Wake Forest Baptist Medical Center /ID# 276952
Winston-Salem, North Carolina 27157
United States
Sanford Fargo Medical Center - Fargo /ID# 275489
Fargo, North Dakota 58102
United States
Cleveland Clinic - Cleveland /ID# 276133
Cleveland, Ohio 44195
United States
Cleveland Clinic - Cleveland /ID# 278273
Cleveland, Ohio 44195
United States
Cleveland Clinic - Cleveland /ID# 278274
Cleveland, Ohio 44195
United States
The Mark H Zangmeister Center /ID# 275106
Columbus, Ohio 43219
United States
Kettering Medical Center /ID# 274365
Kettering, Ohio 45429
United States
Oncology Associates of Oregon, P.C. /ID# 275006
Eugene, Oregon 97401
United States
Compass Oncology - West - Tigard /ID# 275101
Tigard, Oregon 97223
United States
St. Lukes University Hospital /ID# 274362
Bethlehem, Pennsylvania 18015
United States
University of Pennsylvania /ID# 275612
Philadelphia, Pennsylvania 19104
United States
Women & Infants Hospital /ID# 274716
Providence, Rhode Island 02905
United States
Sanford Cancer Center /ID# 274901
Sioux Falls, South Dakota 57104
United States
Avera Cancer Institute - Sioux Falls /ID# 276226
Sioux Falls, South Dakota 57105
United States
Texas Oncology - Austin Central /ID# 275046
Austin, Texas 78731
United States
Texas Oncology - Fort Worth Cancer Center /ID# 275043
Fort Worth, Texas 76104
United States
Houston Methodist Hospital /ID# 274568
Houston, Texas 77030
United States
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 275090
San Antonio, Texas 78240
United States
Texas Oncology - The Woodlands /ID# 275015
The Woodlands, Texas 77380
United States
Texas Oncology - Northeast Texas /ID# 275057
Tyler, Texas 75702
United States
UVA Health University Hospital /ID# 275309
Charlottesville, Virginia 22903
United States
Inova Schar Cancer Institute - Fairfax - Innovation Park Drive /ID# 276456
Fairfax, Virginia 22031
United States
Virginia Oncology Associates- Norfolk (Brock) /ID# 275227
Norfolk, Virginia 23502-2800
United States
Carilion Roanoke Memorial Hospital /ID# 274684
Roanoke, Virginia 24014
United States
Providence Sacred Heart Medical Center & Children'S Hospital /ID# 274585
Spokane, Washington 99204
United States
West Virginia University School of Medicine /ID# 274556
Morgantown, West Virginia 26506
United States