Back to Trials
NCT04543461RecruitingAccepts Healthy Volunteers

American Lung Association (ALA) Lung Health Cohort

Johns Hopkins University

Start Date

10/29/2021

Completion Date

9/1/2026

Summary

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Detailed Description

The scientific goal of the study is to establish the relationship between a variety of factors (lifetime environmental exposures, fitness and physical activity, biomarkers, nasal respiratory epithelial transcriptome) and ideal versus impaired peak lung health (reserve and markers of susceptibility in investigators' model) in young adulthood. In addition to the initial baseline assessment, remote contacts (e.g., via text message, email, mail, or phone) at regular intervals will allow for both the retention of the participants as well as the collection of additional short-term follow-up information, i.e., within 4.5 years of enrollment. If additional funding becomes available, investigators will extend the study for an additional period of time to study factors related to long-term changes in lung health over time, i.e., at 5 years and beyond. Recruitment of participants will be conducted by the participating study sites along with national and regional efforts from the American Lung Association. Recruitment efforts will be supported by the study web site www.lung.org/lung-study

Eligibility Criteria

Age Range: 25 years to 35 years

Inclusion Criteria: 1- Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation. 5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant Exclusion Criteria: 1. Severe asthma, which is defined as any of the following: 1. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = \>250 fluticasone, propionate =100 fluticasone furoate, \>200 beclomethasone, \>400 budesonide, \>220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS. OR 2. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR 3. One asthma hospitalization in the past 12 months 2. History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension 3. Current pregnancy 4. History of cancer other than non-melanoma skin cancer 5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease) 6. Inability to comply with study procedures, including 1. Inability or unwillingness to provide informed consent 2. Inability to perform study measurements 3. Inability to be contacted by phone (via calls and/or text messaging) or email 7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit). 8. Institutionalization

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Lung Diseases

Locations

University Of Alabama

Birmingham, Alabama 35294

United States

University of Arizona-Tuscon

Tucson, Arizona 85724

United States

University of California, Los Angeles

Los Angeles, California 90095

United States

University of California, San Francisco

San Francisco, California 94143

United States

University of Colorado

Aurora, Colorado 80045

United States

National Jewish Health

Denver, Colorado 80206

United States

Nemours Children's Jacksonville

Jacksonville, Florida 32207

United States

University of Florida, Jacksonville

Jacksonville, Florida 32209

United States

University of Illinois at Chicago

Chicago, Illinois 60608

United States

Northwestern University

Chicago, Illinois 60611

United States

Rush Universtiy

Chicago, Illinois 60612

United States

University of Chicago

Chicago, Illinois 60637

United States

St. Vincent's Health System

Indianapolis, Indiana 46260

United States

University of Iowa

Iowa City, Iowa 52242

United States

University of Kansas

Kansas City, Kansas 66103

United States

Johns Hopkins University

Baltimore, Maryland 21218

United States

Brigham and Women's

Boston, Massachusetts 02115

United States

University of Michigan

Ann Arbor, Michigan 48109

United States

Presbyterian Brooklyn Methodist Hospital

Brooklyn, New York 11215

United States

New York Medical College

Hawthorne, New York 10532

United States

New York University

New York, New York 10016

United States

Mt. Sinai, NYC

New York, New York 10029

United States

Columbia University

New York, New York 10032

United States

Cornell University

New York, New York 10032

United States

University of Rochester

Rochester, New York 14642

United States

University of North Carolina Hospital

Chapel Hill, North Carolina 27517

United States

Duke University

Durham, North Carolina 27710

United States

Wake Forest School of Medicine

Winston-Salem, North Carolina 27104

United States

Ohio State University

Columbus, Ohio 43210

United States

Temple University

Philadelphia, Pennsylvania 19140

United States

University of Pittsburg-Emphysema/COPD Research Center

Pittsburgh, Pennsylvania 15213

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

Vanderbilt University Medical Center

Nashville, Tennessee 37235

United States

Baylor College of Medicine

Houston, Texas 77030

United States

University of Vermont

Colchester, Vermont 05446

United States

University of Washington

Seattle, Washington 98108

United States

University of Wisconsin Madison

Madison, Wisconsin 53792

United States