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NCT04994015Recruiting

Parkinson's Foundation PD GENEration Genetic Registry

Parkinson's Foundation

Start Date

12/20/2020

Completion Date

7/1/2026

Summary

Development of a central repository for PD-related genomic data for future research.

Detailed Description

The purpose of this study is to develop a central repository for PD-related genomic data by individuals who consent to deposit their data and bank their residual DNA obtained through clinical genetic testing for future research use.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Study Population 1: PWP (open for recruitment) 1. Meet Movement Disorder Society (MDS) Clinical Diagnostic Criteria for Parkinson's Disease: probable diagnosis. 2. Willingness to undergo genetic testing, and choose to be informed of genetic testing results for GBA, LRRK2 and 5 additional PD related genes (SNCA, VPS35, PRKN, PINK-1, PARK7). 3. Capacity to give full informed consent in writing or electronically, and have read and signed the informed consent forms (ICFs) based on site clinician's determination. 4. Able to perform study activities (including completion of either online, in-person or paper surveys). Study Population 2: People at risk of developing PD (not open for recruitment) 1\. Family members of Study Population 1 may be invited to participate in the study if confirmatory genetic testing is deemed necessary by the genetic testing laboratory. Exclusion Criteria: 1. Diagnosis of an atypical parkinsonian disorder (i.e., multiple system atrophy, progressive supranuclear palsy, dementia with Lewy bodies, corticobasal syndrome), including that due to medications, metabolic disorders, encephalitis, cerebrovascular disease, or normal pressure hydrocephalus. 2. Individuals who have received a blood transfusion within the past 3 months. 3. Individuals who have active hematologic malignancies such as lymphoma or leukemia. 4. Individuals who have had a bone marrow transplant within the past 5 years. 5. Under the age of 18

Interventions

DEVICE

Lab Assay for seven genetic variants for Parkinson's Disease

Interested in This Trial?

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Conditions

Parkinson's Disease

Locations

University of Alabama Birmingham

Birmingham, Alabama 35294

United States

MD First Research

Chandler, Arizona 85286

United States

Barrow Neurological Institute

Phoenix, Arizona 85013

United States

University of Arkansas

Fayetteville, Arkansas 72701

United States

University of California San Diego (UCSD)

La Jolla, California 92093

United States

University of California Los Angeles

Los Angeles, California 90095

United States

University of California San Francisco (UCSF)

San Francisco, California 94143

United States

University of Colorado Anschutz

Aurora, Colorado 80045

United States

Hartford Healthcare

Hartford, Connecticut 06066

United States

Aventura Neurology - Visionary Investigators Network

Aventura, Florida 33180

United States

Parkinson's Disease & Movement Disorder Center of Boca Raton

Boca Raton, Florida 33486

United States

University of Florida

Gainesville, Florida 32611

United States

University of Miami

Miami, Florida 33131

United States

Cleveland Clinic Weston

Weston, Florida 33331

United States

Morehouse College

Atlanta, Georgia 30314

United States

The Queen's Health System

Honolulu, Hawaii 96813

United States

University of Illinois-Chicago

Chicago, Illinois 60607

United States

Rush University

Chicago, Illinois 60612

United States

University of Chicago

Chicago, Illinois 60637

United States

Northwestern University

Evanston, Illinois 60208

United States

Indiana University

Indianapolis, Indiana 46202

United States

University of Iowa

Iowa City, Iowa 52242

United States

University of Kansas

Lawrence, Kansas 66045

United States

University of Kentucky

Lexington, Kentucky 40506

United States

Louisiana State University

Shreveport, Louisiana 71103

United States

Johns Hopkins

Baltimore, Maryland 21218

United States

University of Maryland

College Park, Maryland 20742

United States

Massachusetts General Hospital (MGH)

Boston, Massachusetts 02114

United States

BMC Community Hospital

Boston, Massachusetts 02136

United States

Beth Israel Deaconess Medical Center (BIDMC)

Boston, Massachusetts 02215

United States

Struthers Parkinson's Center - HealthPartners Park Nicollet

Golden Valley, Minnesota 55427

United States

Rutgers University

New Brunswick, New Jersey 08854

United States

University of New Mexico

Albuquerque, New Mexico 87106

United States

New York University

New York, New York 10017

United States

Mount Sinai

New York, New York 10029

United States

Columbia University

New York, New York 10033

United States

University of North Carolina - Chapel Hill

Chapel Hill, North Carolina 27599

United States

Atrium Health

Charlotte, North Carolina 28207

United States

University of Cincinnati

Cincinnati, Ohio 45221

United States

Case Western Reserve University

Cleveland, Ohio 44106

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States

Ohio State University

Columbus, Ohio 43210

United States

Oregon Health and Science University

Portland, Oregon 97239

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

Thomas Jefferson University

Philadelphia, Pennsylvania 19144

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

Vanderbilt University

Nashville, Tennessee 37235

United States

Baylor College of Medicine

Houston, Texas 77030

United States

University of Texas at San Antonio

San Antonio, Texas 78249

United States

Intermountain Health

Murray, Utah 84107

United States

Virginia Commonwealth University

Richmond, Virginia 23284

United States

Evergreen Health

Kirkland, Washington 98034

United States

Inland Northwest Research

Spokane, Washington 99202

United States

Medical College of Wisconsin

Milwaukee, Wisconsin 53226

United States

Toronto Western Hospital

Toronto, Ontario

Canada

Tel Aviv Sourasky Medical Center

Tel Aviv, 64239

Israel