A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
Start Date
8/17/2022
Completion Date
3/24/2032
Summary
This study is researching an experimental drug called linvoseltamab in combination with other drugs for the treatment of a blood cancer called multiple myeloma. Linvoseltamab has previously been studied as a single agent (without other cancer treatments) in participants with multiple myeloma that returned after prior therapies and needed to be treated again. In the initial study, some participants treated with linvoseltamab had improvement of their myeloma, including complete responses (no evidence of myeloma in their bodies). This study is the first time linvoseltamab will be combined with other cancer therapies. The main goal is to understand if linvoseltamab can be given safely with other cancer treatments, and if so, what dose of linvoseltamab should be used for each combination. The study is looking at several other research questions, including: * How many participants treated with linvoseltamab in combination with each of the other cancer treatments have improvement of their multiple myeloma * What side effects may happen from taking linvoseltamab together with another cancer treatment * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Linvoseltamab
Daratumumab
Carfilzomib
Lenalidomide
Bortezomib
Pomalidomide
Isatuximab
Fianlimab
Cemiplimab
Nirogacestat
Cevostamab
Conditions
Locations
Scripps Clinic Torrey Pines
La Jolla, California 92037
United States
Winship Cancer Institute of Emory University
Atlanta, Georgia 30004
United States
Indiana University Health Simon Cancer Center
Indianapolis, Indiana 46202
United States
Dana Farber/Harvard Cancer Center
Boston, Massachusetts 02215
United States
Karmanos Cancer Institute
Detroit, Michigan 48201
United States
Mayo Clinic
Rochester, Minnesota 55905
United States
Weill Cornell Medicine/New York Presbyterian Hospital
New York, New York 10021
United States
New York Presbyterian Hospital Columbia University Medical Center
New York, New York 10032
United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27599
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
United States
The Ohio State University James Cancer Hospital
Columbus, Ohio 43210
United States
University of Texas Southwestern
Dallas, Texas 75390
United States
VA Puget Sound Health Care System
Seattle, Washington 98108
United States
Centre Hospitalier Universitaire (CHU) de Poitiers
Poitiers, New Aquitaine 86021
France
CHU de Lille - Rue Michel Polonovski
Lille, Nord 59037
France
Nantes University Hospital
Nantes, Pays de la Loire Region 44093
France
Centre Hospitalier Universitaire Angers
Angers, 49933
France
CHU Montpellier - Departement D'Hematologie
Montpellier, 34295
France
Saint Antoine Hospital
Paris, 75571
France
Institut Gustave Roussy
Villejuif, 94805
France
Hospital Henri Mondor
Créteil, Île-de-France Region 94000
France
Saint Louis Hospital
Paris, Île-de-France Region 75010
France
Hopital Necker
Paris, Île-de-France Region 75015
France
Evangelismos General Hospital
Athens, Attica 10676
Greece
General Hospital of Athens Alexandra
Athens, 11528
Greece
Sheba Medical Center
Ramat Gan, Central District 5265601
Israel
Rambam Health Care Campus
Haifa, 3109601
Israel
Hadassah Medical Center
Jerusalem, 91120
Israel
Hospital Clinico Universitario de Santiago
Santiago de Compostela, A Coruna 15706
Spain
Hospital Germans Trias i Pujol
Badalona, Barcelona 08916
Spain
Hospital Universitario Marques de Valdecilla
Santander, Cantabria 39008
Spain
Hospital Universitario Quiron Salud Madrid
Pozuelo de Alarcón, Madrid 28223
Spain
Clinica Universidad de Navarra
Pamplona, Navarre 31008
Spain
Hospital Universitario Vall d'Hebron
Barcelona, 08035
Spain
Hospital Clinic de Barcelona
Barcelona, 08036
Spain
Institut Catala d'Oncologia (ICO) - Hospital Duran i Reynals,
Barcelona, 08908
Spain
Universitaru Hospital La Princesa
Madrid, 28006
Spain
Clinica Universidad de Navarra - Madrid
Madrid, 28027
Spain
Hospital Universitario Ramon y Cajal - Servicio de Psiquiatria
Madrid, 28034
Spain
University Hospital and Research Institute
Madrid, 28041
Spain
Hospital Universitario HM Sanchinarro
Madrid, 28050
Spain
University Hospital of Salamanca
Salamanca, 37007
Spain