NCT06451133NARecruiting
Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
The University of Texas Health Science Center, Houston
Start Date
7/3/2024
Completion Date
7/31/2026
Summary
The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Traumatic spinal cord injury
Exclusion Criteria:
* Patients with an injury from a trauma that penetrates the spinal cord (i.e., gunshot or knife wound resulting in cord transection)
* Preexisting neurologic or spinal cord injury
* Severe traumatic brain injury as measured by a best resuscitated Glasgow Coma Scale (GCS) score of \<8 at 24 hours following injury
* Presence of traumatic injuries that preclude spine surgery within 24 hours of presentation
* Concomitant injury/illness requiring targeted blood pressure management (e.g., injury to the aorta, aortic dissection, hemorrhagic stroke)
* Preexisting history of neuromotor disorders (i.e., cerebral palsy, Parkinson disease, etc.)
* Not expected to survive \>24h
* Cord transection identified by radiologist and agreed upon by the spine surgery team
* Injury below spinal cord level L1
* Prisoners
* Pregnant women
Interventions
OTHER
Mean arterial blood pressure (MAP) goal of ≥65 mmHg
OTHER
Mean arterial blood pressure (MAP) goal of 85-90 mmHg
OTHER
Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg
Conditions
Spinal Cord Injuries
Locations
The University of Texas Health Science Center at Houston
Houston, Texas 77030
United States