A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
Start Date
8/11/2025
Completion Date
11/4/2027
Summary
Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each cancer type in this study. The goal of this study is to learn if people who receive MK-5684 live longer without the cancer growing or spreading compared to people who receive a standard treatment.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Opevesostat
Fludrocortisone/ Fludrocortisone acetate
Dexamethasone/Dexamethasone acetate
Rescue Medications
Fulvestrant
Exemestane
Megestrol acetate/Medroxyprogesterone acetate
Tamoxifen
Letrozole
Conditions
Locations
Alaska Womens Cancer Care ( Site 0037)
Anchorage, Alaska 99508
United States
Mount Sinai Cancer Center ( Site 0009)
Miami Beach, Florida 33140
United States
TRIALS 365 ( Site 0022)
Shreveport, Louisiana 71103
United States
Mary Lanning Healthcare ( Site 0019)
Hastings, Nebraska 68901
United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0021)
Hackensack, New Jersey 07601
United States
Rockefeller Outpatient Pavilion ( Site 0002)
New York, New York 10022
United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0008)
Columbus, Ohio 43210
United States
Baylor College of Medicine Medical Center ( Site 0004)
Houston, Texas 77030
United States
Harris Health System ( Site 0040)
Houston, Texas 77054
United States
Mays Cancer Center ( Site 0039)
San Antonio, Texas 78229
United States
Hospital Aleman ( Site 0301)
Ciudad Autonoma de Buenos Aires, Buenos Aires C1118AAT
Argentina
Centro Medico Dr. Doreski - Fundación Respirar ( Site 0302)
Buenos Aires, Buenos Aires F.D. C1118AAT
Argentina
Instituto Alexander Fleming ( Site 0303)
Buenos Aires, Buenos Aires F.D. C1426ANZ
Argentina
Hospital Santa Rita de Cassia ( Site 3104)
Vitória, Espírito Santo 29043-260
Brazil
Obras Sociais Irma Dulce ( Site 3112)
Salvador, Estado de Bahia 41680-430
Brazil
Hospital Felicio Rocho ( Site 3105)
Belo Horizonte, Minas Gerais 30110-934
Brazil
Hospital de Cancer de Pernambuco ( Site 3103)
Recife, Pernambuco 50040-000
Brazil
Liga Norte Riograndense Contra o Cancer ( Site 3108)
Natal, Rio Grande do Norte 59062-000
Brazil
Instituto Nacional de Câncer - INCA ( Site 3107)
Rio de Janeiro, 20230-130
Brazil
Princess Margaret Cancer Centre ( Site 0202)
Toronto, Ontario M5G 2M9
Canada
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0200)
Montreal, Quebec H2X 0C1
Canada
Jewish General Hospital ( Site 0201)
Montreal, Quebec H3T 1E2
Canada
FALP ( Site 3300)
Santiago, Region M. de Santiago 7500921
Chile
Pontificia Universidad Catolica de Chile ( Site 3307)
Santiago, Region M. de Santiago 8330032
Chile
Bradfordhill ( Site 3301)
Santiago, Region M. de Santiago 8420383
Chile
ONCOCENTRO APYS ( Site 3302)
Viña del Mar, Valparaiso 2520598
Chile
Sarawak General Hospital ( Site 0602)
Kuching, Sarawak 93586
Malaysia
Pantai Hospital Kuala Lumpur ( Site 0603)
Kuala Lumpur, 59100
Malaysia
University Malaya Medical Centre ( Site 0601)
Kuala Lumpur, 59100
Malaysia
Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 3405)
Concepción, Departamento de Junín 12125
Peru
Clínica San Antonio ( Site 3404)
Trujillo, La Libertad 13008
Peru
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3400)
Lima, 15036
Peru
Instituto Nacional de Enfermedades Neoplásicas ( Site 3401)
Lima, 15038
Peru
National Cancer Centre Singapore ( Site 0800)
Singapore, Central Singapore 168583
Singapore
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2000)
L'Hospitalet de Llobregat, Barcelona 08908
Spain
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2003)
A Coruña, La Coruna 15006
Spain
Clinica Universitaria Navarra - Madrid ( Site 2004)
Madrid, Madrid, Comunidad de 28027
Spain
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2002)
Madrid, Madrid, Comunidad de 28034
Spain
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2001)
Madrid, 28223
Spain
Taichung Veterans General Hospital ( Site 1004)
Taichung, 407
Taiwan
National Cheng Kung University Hospital ( Site 1003)
Tainan, 704
Taiwan
Mackay Memorial Hospital ( Site 1002)
Taipei, 10449
Taiwan
Chulalongkorn Hospital ( Site 1114)
Bangkok, Bangkok 10330
Thailand
Faculty of Medicine Siriraj Hospital ( Site 1111)
Bangkok, Bangkok 10700
Thailand
Songklanagarind Hospital ( Site 1113)
Songkhla, 90110
Thailand
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2201)
Adana, 01240
Turkey (Türkiye)
Hacettepe Universitesi ( Site 2200)
Ankara, 06230
Turkey (Türkiye)
Trakya Üniversitesi Eğitim Araştırma Hastanesi ( Site 2204)
Edirne, 22030
Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa ( Site 2203)
Istanbul, 34098
Turkey (Türkiye)
Koc University, School of Medicine ( Site 2202)
Istanbul, 34450
Turkey (Türkiye)
University Hospitals Sussex NHS Foundation Trust ( Site 2301)
East Sussex, Brighton And Hove BN2 1ES
United Kingdom
The Royal Cornwall Hospital ( Site 2306)
Truro, Cornwall TR1 3LJ
United Kingdom
St Bartholomew's Hospital ( Site 2302)
London, London, City of EC1A 7BE
United Kingdom
University College Hospital London ( Site 2303)
London, London, City of NW1 2PG
United Kingdom
Guy's & St Thomas' NHS Foundation Trust ( Site 2309)
London, London, City of SE1 9RT
United Kingdom
Western General Hospital ( Site 2307)
Edinburgh, Midlothian EH4 2XU
United Kingdom
Queen Elizabeth Hospital ( Site 2305)
Birmingham, B15 2GW
United Kingdom
The Christie NHS Foundation Trust ( Site 2300)
Manchester, M20 4BX
United Kingdom