TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Start Date
7/2/2025
Completion Date
11/30/2032
Summary
The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life
Eligibility Criteria
Age Range: 18 years to 85 years
Interventions
Nucresiran
Sterile Normal Saline (0.9% NaCl)
Conditions
Locations
Clinical Trial Site
La Jolla, California 92037
United States
Clinical Trial Site
Stanford, California 94305
United States
Clinical Trial Site
Norwich, Connecticut 06360
United States
Clinical Trial Site
Washington D.C., District of Columbia 20010
United States
Clinical Trial Site
Brandon, Florida 33511
United States
Clinical Trial Site
Miami, Florida 33125
United States
Clinical Trial Site
Atlanta, Georgia 30309
United States
Clinical Trial Site
Gainesville, Georgia 30501
United States
Clinical Trial Site
Tucker, Georgia 30084
United States
Clinical Trial Site
Evanston, Illinois 60201
United States
Clinical Trial Site
Indianapolis, Indiana 46202
United States
Clinical Trial Site
Indianapolis, Indiana 46260
United States
Clinical Trial Site
Kansas City, Kansas 66160
United States
Clinical Trial Site
Baltimore, Maryland 21287
United States
Clinical Trial Site
Boston, Massachusetts 02115
United States
Clinical Trial Site
Boston, Massachusetts 02118
United States
Clinical Trial Site
Detroit, Michigan 48202
United States
Clinical Trial Site
Rochester, Minnesota 55905
United States
Clinical Trial Site
St Louis, Missouri 63110
United States
Clinical Trial Site
Manhasset, New York 11030
United States
Clinical Trial Site
New York, New York 10029
United States
Clinical Trial Site
New York, New York 10032
United States
Clinical Trial Site
New York, New York 10065
United States
Clinical Trial Site
The Bronx, New York 10467
United States
Clinical Trial Site
Charlotte, North Carolina 28204
United States
Clinical Trial Site
Cleveland, Ohio 44195
United States
Clinical Trial Site
Columbus, Ohio 43210
United States
Clinical Trial Site
Portland, Oregon 97239
United States
Clinical Trial Site
Lancaster, Pennsylvania 17602
United States
Clinical Trial Site
Philadelphia, Pennsylvania 19104
United States
Clinical Trial Site
Charleston, South Carolina 29425
United States
Clinical Trial Site
Dallas, Texas 75246
United States
Clinical Trial Site
Houston, Texas 77030
United States
Clinical Trial Site
Plano, Texas 75024
United States
Clinical Trial Site
Salt Lake City, Utah 84132
United States
Clinical Trial Site
Charlottesville, Virginia 22903
United States
Clinical Trial Site
Falls Church, Virginia 22042
United States
Clinical Trial Site
Norfolk, Virginia 23507
United States
Clinical Trial Site
Richmond, Virginia 23298
United States
Clinical Trial Site
Spokane, Washington 99204
United States
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Buenos Aires, C1025ABI
Argentina
Clinical Trial Site
Buenos Aires, C1093AAS
Argentina
Clinical Trial Site
Buenos Aires, C1199ABB
Argentina
Clinical Trial Site
Buenos Aires, C1428
Argentina
Clinical Trial Site
Córdoba, X5016KET
Argentina
Clinical Trial Site
Rosario, S2000DEJ
Argentina
Clinical Trial Site
Rosario, S2000DSR
Argentina
Clinical Trial Site
Rosario, S2000GAP
Argentina
Clinical Trial Site
Adelaide, 5000
Australia
Clinical Trial Site
Bedford Park, 5042
Australia
Clinical Trial Site
Box Hill, 3128
Australia
Clinical Trial Site
Chermside, 4032
Australia
Clinical Trial Site
Darlinghurst, 2010
Australia
Clinical Trial Site
Joondalup, 6027
Australia
Clinical Trial Site
Liverpool, 2170
Australia
Clinical Trial Site
Westmead, 2145
Australia
Clinical Trial Site
Braunau am Inn, 5280
Austria
Clinical Trial Site
Graz, 8036
Austria
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Vienna, 1090
Austria
Clinical Trial Site
Vienna, 1100
Austria
Clinical Trial Site
Vienna, 1160
Austria
Clinical Trial Site
Vienna, 1210
Austria
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Wels, 4600
Austria
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Aalst, 9300
Belgium
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Bruges, 8000
Belgium
Clinical Trial Site
Brussels, 1200
Belgium
Clinical Trial Site
Dendermonde, 9200
Belgium
Clinical Trial Site
Genk, 3600
Belgium
Clinical Trial Site
Ghent, 9000
Belgium
Clinical Trial Site
Hasselt, 3500
Belgium
Clinical Trial Site
Leuven, 3000
Belgium
Clinical Trial Site
Liège, 4000
Belgium
Clinical Trial Site
Roeselare, 8800
Belgium
Clinical Trial Site
Belo Horizonte, 30220-140
Brazil
Clinical Trial Site
Porto Alegre, 90035-903
Brazil
Clinical Trial Site
Porto Alegre, 90560-032
Brazil
Clinical Trial Site
Ribeirão Preto, 14026-900
Brazil
Clinical Trial Site
Ribeirão Preto, 14051-140
Brazil
Clinical Trial Site
Rio de Janeiro, 20551-030
Brazil
Clinical Trial Site
Salvador, 40170-130
Brazil
Clinical Trial Site
São Paulo, 04038-002
Brazil
Clinical Trial Site
São Paulo, 05403-000
Brazil
Clinical Trial Site
Calgary, T2N 4N1
Canada
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London, N6A 5A5
Canada
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Vancouver, V6Z 1Y6
Canada
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Santiago, 7500588
Chile
Clinical Trial Site
Santiago, 8320000
Chile
Clinical Trial Site
Binhai, 300456
China
Clinical Trial Site
Changsha, 410013
China
Clinical Trial Site
Dongcheng, 100006
China
Clinical Trial Site
Fuzhou, 350004
China
Clinical Trial Site
Haidian, 100191
China
Clinical Trial Site
Hangzhou, 310009
China
Clinical Trial Site
Xicheng, 100034
China
Clinical Trial Site
Brno, 602 00
Czechia
Clinical Trial Site
Ostrava, 708-52
Czechia
Clinical Trial Site
Prague, 128 21
Czechia
Clinical Trial Site
Prague, 140 21
Czechia
Clinical Trial Site
Aarhus N, 8200
Denmark
Clinical Trial Site
København Ø, 2100
Denmark
Clinical Trial Site
Odense C, 5000
Denmark
Clinical Trial Site
Chambray-lès-Tours, 37170
France
Clinical Trial Site
Créteil, 94000
France
Clinical Trial Site
Dijon, 21000
France
Clinical Trial Site
La Tronche, 38700
France
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Marseille, 13005
France
Clinical Trial Site
Martinique, 97261
France
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Montpellier, 34295
France
Clinical Trial Site
Paris, 75015
France
Clinical Trial Site
Paris, 75018
France
Clinical Trial Site
Pessac, 33600
France
Clinical Trial Site
Reims, 51100
France
Clinical Trial Site
Rennes, 35000
France
Clinical Trial Site
Rouen, 76031
France
Clinical Trial Site
Saint-Herblain, 44093
France
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Strasbourg, 67091
France
Clinical Trial Site
Toulouse, 31059
France
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Berlin, 13353
Germany
Clinical Trial Site
Cologne, 50937
Germany
Clinical Trial Site
Dresden, 01307
Germany
Clinical Trial Site
Göttingen, 37075
Germany
Clinical Trial Site
Hanover, 30625
Germany
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Heidelberg, 69120
Germany
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Leipzig, 04103
Germany
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Magdeburg, 39120
Germany
Clinical Trial Site
Munich, 81377
Germany
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Münster, 48149
Germany
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Würzburg, 97080
Germany
Clinical Trial Site
Athens, 115 27
Greece
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Athens, 115 28
Greece
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Heraklion, 714 09
Greece
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Thessaloniki, 546 36
Greece
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Hong Kong, 999077
Hong Kong
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Balatonfüred, 8230
Hungary
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Budapest, 1085
Hungary
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Dublin, D07 R2WY
Ireland
Clinical Trial Site
Dublin, D08 NHY1
Ireland
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Be’er Ya‘aqov, 70300
Israel
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Haifa, 3109601
Israel
Clinical Trial Site
Jerusalem, 91120
Israel
Clinical Trial Site
Petah Tikva, 4941492
Israel
Clinical Trial Site
Ancona, 60126
Italy
Clinical Trial Site
Bologna, 40138
Italy
Clinical Trial Site
Brescia, 25123
Italy
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Florence, 50134
Italy
Clinical Trial Site
Forlì, 47121
Italy
Clinical Trial Site
Lecce, 73100
Italy
Clinical Trial Site
Milan, 20122
Italy
Clinical Trial Site
Naples, 80131
Italy
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Padova, 35128
Italy
Clinical Trial Site
Pavia, 27100
Italy
Clinical Trial Site
Pisa, 56124
Italy
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Rimini, 47923
Italy
Clinical Trial Site
Roma, 00168
Italy
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Rome, 00161
Italy
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Torino, 10126
Italy
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Bunkyō City, 113-8655
Japan
Clinical Trial Site
Fukuoka, 810-0001
Japan
Clinical Trial Site
Fukuoka, 812-8582
Japan
Clinical Trial Site
Kagawa, 761-0793
Japan
Clinical Trial Site
Kashihara, 634-8522
Japan
Clinical Trial Site
Kobe, 650-0017
Japan
Clinical Trial Site
Kumamoto, 860-8556
Japan
Clinical Trial Site
Kurume, 830-0011
Japan
Clinical Trial Site
Matsumoto-shi, 390-8621
Japan
Clinical Trial Site
Nagoya, 466-8560
Japan
Clinical Trial Site
Nankoku, 783-0043
Japan
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Niigata, 951-8520
Japan
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Okayama, 700-8558
Japan
Clinical Trial Site
Sapporo, 060-8543
Japan
Clinical Trial Site
Sapporo, 060-8648
Japan
Clinical Trial Site
Sendai, 980-8574
Japan
Clinical Trial Site
Suita, 564-8565
Japan
Clinical Trial Site
Tokyo, 160-8582
Japan
Clinical Trial Site
Kajang, 43000
Malaysia
Clinical Trial Site
Kuala Lumpur, 59100
Malaysia
Clinical Trial Site
Eindhoven, 5623 EJ
Netherlands
Clinical Trial Site
Groningen, 9713 GZ
Netherlands
Clinical Trial Site
Maastricht, 6229 HX
Netherlands
Clinical Trial Site
Rotterdam, 3015 GD
Netherlands
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Utrecht, 3584 CX
Netherlands
Clinical Trial Site
Auckland, 2025
New Zealand
Clinical Trial Site
Christchurch, 8011
New Zealand
Clinical Trial Site
Hamilton, 3204
New Zealand
Clinical Trial Site
Ålesund, 6017
Norway
Clinical Trial Site
Lørenskog, 1478
Norway
Clinical Trial Site
Lodz, 93-338
Poland
Clinical Trial Site
Carnaxide, 2790-134
Portugal
Clinical Trial Site
Creixomil, 4835-044
Portugal
Clinical Trial Site
Leiria, 2410-197
Portugal
Clinical Trial Site
Lisbon, 1169-024
Portugal
Clinical Trial Site
Lisbon, 1649-035
Portugal
Clinical Trial Site
Vila Real, 5000-508
Portugal
Clinical Trial Site
Viseu, 3504-509
Portugal
Clinical Trial Site
Bucharest, 022328
Romania
Clinical Trial Site
Cluj-Napoca, 400001
Romania
Clinical Trial Site
Košice, 040 11
Slovakia
Clinical Trial Site
Incheon, 22332
South Korea
Clinical Trial Site
Seoul, 03080
South Korea
Clinical Trial Site
Seoul, 03722
South Korea
Clinical Trial Site
Seoul, 06351
South Korea
Clinical Trial Site
Seoul, 06591
South Korea
Clinical Trial Site
A Coruña, 15006
Spain
Clinical Trial Site
Barcelona, 08035
Spain
Clinical Trial Site
Barcelona, 08036
Spain
Clinical Trial Site
Bilbao, 48013
Spain
Clinical Trial Site
El Palmar, 30120
Spain
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Huelva, 21005
Spain
Clinical Trial Site
Jaén, 23007
Spain
Clinical Trial Site
L'Hospitalet de Llobregat, 8907
Spain
Clinical Trial Site
Lleida, 25198
Spain
Clinical Trial Site
Madrid, 28046
Spain
Clinical Trial Site
Madrid, 28222
Spain
Clinical Trial Site
Palma de Mallorca, 07198
Spain
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Pamplona, 31008
Spain
Clinical Trial Site
Salamanca, 37007
Spain
Clinical Trial Site
Santiago de Compostela, 15706
Spain
Clinical Trial Site
Valencia, 46010
Spain
Clinical Trial Site
Valencia, 46026
Spain
Clinical Trial Site
Vigo, 36213
Spain
Clinical Trial Site
Gothenburg, 413 45
Sweden
Clinical Trial Site
Lund, 222 42
Sweden
Clinical Trial Site
Solna, 171 76
Sweden
Clinical Trial Site
Basel, 4051
Switzerland
Clinical Trial Site
Geneva, 1205
Switzerland
Clinical Trial Site
Lucerne, 6000
Switzerland
Clinical Trial Site
Sankt Gallen, 9007
Switzerland
Clinical Trial Site
New Taipei City, 220
Taiwan
Clinical Trial Site
Taichung, 40705
Taiwan
Clinical Trial Site
Taipei, 10002
Taiwan
Clinical Trial Site
Taipei, 112
Taiwan
Clinical Trial Site
Ankara, 06170
Turkey (Türkiye)
Clinical Trial Site
Antalya, 07070
Turkey (Türkiye)
Clinical Trial Site
Istanbul, 34093
Turkey (Türkiye)
Clinical Trial Site
Bellshill, ML4 3NJ
United Kingdom
Clinical Trial Site
Birmingham, B15 2SQ
United Kingdom
Clinical Trial Site
Cardiff, CF15 9SS
United Kingdom
Clinical Trial Site
London, NW10 2PB
United Kingdom
Clinical Trial Site
London, NW3 2QG
United Kingdom
Clinical Trial Site
Manchester, M15 6SE
United Kingdom