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NCT07136012PHASE3Recruiting

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Amgen

Start Date

8/22/2025

Completion Date

10/20/2031

Summary

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Eligibility Criteria

Age Range: 50 years to 105 years

Inclusion Criteria: * Age ≥50 years * Lp(a)≥ 200 nmol/L during screening * Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis Exclusion Criteria: * Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia) * Prior or planned arterial revascularization * History of major bleeding disorder

Interventions

DRUG

Olpasiran

DRUG

Placebo

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Conditions

Cardiovascular Disease

Locations

Advanced Cardiovascular LLC

Alexander City, Alabama 35010

United States

University of Alabama Birmingham Saint Vincents Birmingham

Birmingham, Alabama 35205

United States

Birmingham Clinical Research

Birmingham, Alabama 35209

United States

Alliance For Multispecialty Research - Daphne

Daphne, Alabama 36526

United States

Eastern Shore Research Institute

Fairhope, Alabama 36532

United States

Heart Center Research LLC

Huntsville, Alabama 35801

United States

CB Flock Research Corporation

Mobile, Alabama 36608

United States

Phoenix Clinical

Phoenix, Arizona 85014

United States

Elite Clinical Studies LLC

Phoenix, Arizona 85018

United States

Hero Clinical Research

Phoenix, Arizona 85021

United States

HonorHealth Research Institute

Scottsdale, Arizona 85258

United States

Eclipse Clinical Research

Tucson, Arizona 85745

United States

Lynn Institute of the Ozarks

Little Rock, Arkansas 72204

United States

National Heart Institute

Beverly Hills, California 90211

United States

310 Clinical Research

Inglewood, California 90301

United States

University of California San Diego

La Jolla, California 92037

United States

InvivoCure

Los Angeles, California 91405

United States

Valley Clinical Trials

Northridge, California 91325

United States

Clinical Trials Research - Sacramento

Roseville, California 95661

United States

Alliance Clinical Research

San Diego, California 92120

United States

Encompass Clinical Research

Spring Valley, California 91978

United States

Stanford Health Care

Stanford, California 94305

United States

Manshadi Heart Institute

Stockton, California 95204

United States

Blue Coast Cardiology

Vista, California 92083

United States

Diablo Clinical Research

Walnut Creek, California 94598

United States

Focus Clinical Research

West Hills, California 91307

United States

Interventional Cardiology Medical Group

West Hills, California 91307

United States

UCHealth Memorial Central

Colorado Springs, Colorado 80909

United States

South Denver Cardiology Associates

Littleton, Colorado 80120

United States

Gandelman Cardiology, PC

Greenwich, Connecticut 06830

United States

ClinTrial Hamden

Hamden, Connecticut 06518

United States

Chase Medical Research LLC

Waterbury, Connecticut 06708

United States

Excel Medical Clinical Trials

Boca Raton, Florida 33434

United States

Clearwater Cardiovascular Consultants

Clearwater, Florida 33756

United States

Proactive Clinical Research

Fort Lauderdale, Florida 33308

United States

Elite Cardiac Research Center LLC

Hialeah, Florida 33013

United States

Jacksonville Center for Clinical Research

Jacksonville, Florida 32216

United States

East Coast Institute for Research, LLC

Lake City, Florida 32055

United States

Columbus Clinical Services LLC

Miami, Florida 33125

United States

Kendall South Medical Center

Miami, Florida 33175

United States

Inpatient Research Clinic, LLC

Miami Lakes, Florida 33014

United States

Panax Clinical Research

Miami Lakes, Florida 33014

United States

Indago Research and Health Center

Miami Lakes, Florida 33016

United States

Eminat, LLC

Miramar, Florida 33027

United States

Suncoast Clinical Research Inc

New Port Richey, Florida 34652

United States

Ocala Cardiovascular Research

Ocala, Florida 34471

United States

Ocala Research Institute, Inc

Ocala, Florida 34474

United States

Ormond Beach Clinical Research

Ormond Beach, Florida 32174

United States

Baptist Health Care

Pensacola, Florida 32503

United States

Denali Health Plant City

Plant City, Florida 33563

United States

FWD Clinical Research

Tamarac, Florida 33321

United States

Clinical Site Partners Orlando dba Flourish Research

Winter Park, Florida 32789

United States

Guardian Research Organization LLC

Winter Park, Florida 32792

United States

Emory University Hospital

Atlanta, Georgia 30322

United States

East Coast Institute for Research

Canton, Georgia 30114

United States

Northeast Georgia Medical Center Wisteria Building

Cumming, Georgia 30041

United States

Nsc Research

Johns Creek, Georgia 30024

United States

Georgia Clinical Research

Lawrenceville, Georgia 30044

United States

North Georgia Clinical Research

Woodstock, Georgia 30189

United States

St Lukes Idaho Cardiology Associates

Meridian, Idaho 83642

United States

Solaris Clinical Research

Meridian, Idaho 83646

United States

Endeavor Health-Northwest Community Healthcare

Arlington Heights, Illinois 60005

United States

Christie Clinic

Champaign, Illinois 61822

United States

Advocate Lutheran General Hospital

Park Ridge, Illinois 60068

United States

Alliance for Multispecialty Research LLC - Park Ridge

Park Ridge, Illinois 66068

United States

MediSphere Medical Research Center LLC

Evansville, Indiana 47714

United States

Parkview Research Center

Fort Wayne, Indiana 46845

United States

Franciscan Health Indianapolis

Indianapolis, Indiana 46237

United States

Ascension Saint Vincent Heart Center

Indianapolis, Indiana 46290

United States

Cardiovascular Research of Northwest Indiana LLC

Munster, Indiana 46321

United States

Reid Physician Associates

Richmond, Indiana 47374

United States

MercyOne Iowa Heart Center

West Des Moines, Iowa 50266

United States

Hutchinson Clinic PA

Hutchinson, Kansas 67502

United States

University of Kansas Medical Center

Kansas City, Kansas 66160

United States

Midwest Heart and Vascular Specialists

Overland Park, Kansas 66211

United States

Graves Gilbert Clinic

Bowling Green, Kentucky 42101

United States

Baptist Health Lexington

Lexington, Kentucky 40503

United States

The Research Group of Lexington LLC

Lexington, Kentucky 40503

United States

Heart Clinic of Hammond

Covington, Louisiana 70433

United States

IMA Clinical Research

Monroe, Louisiana 71201

United States

Louisiana Heart Center

Slidell, Louisiana 70458

United States

Monroe Research LLC

West Monroe, Louisiana 71291

United States

Ascension Saint Agnes Heart Care

Baltimore, Maryland 21229

United States

Johns Hopkins Hospital

Baltimore, Maryland 21287

United States

Metropolitan Cardiovascular Consultants LLC

Beltsville, Maryland 20705

United States

Suburban Hospital

Bethesda, Maryland 20814

United States

Flourish Research

Bowie, Maryland 20715

United States

Johns Hopkins University

Columbia, Maryland 21044

United States

Centennial Medical Group

Columbia, Maryland 21045

United States

Medstar Franklin Square Medical Center

Hyattsville, Maryland 20782

United States

Capitol Cardiology Associates

Lanham, Maryland 20706

United States

Brigham and Womens Hospital

Boston, Massachusetts 02115

United States

Henry Ford Health System

Detroit, Michigan 48202

United States

Healthy Heart Cardiology

Grand Rapids, Michigan 49546

United States

MyMichigan Medical Center Midland - Clinical Research Department

Midland, Michigan 48670

United States

Advanced Cardiology Associates

Rochester Hills, Michigan 48307

United States

Revival Research Institute

Southfield, Michigan 48034

United States

Saint Marys Medical Center

Duluth, Minnesota 55805

United States

Health East Cancer Care

Maplewood, Minnesota 55109

United States

University of Minnesota

Minneapolis, Minnesota 55455

United States

Mayo Clinic

Rochester, Minnesota 55905

United States

Methodist Hospital

Saint Louis Park, Minnesota 55426

United States

Jackson Heart Clinic

Jackson, Mississippi 39216

United States

Cardiology Associates Research LLC

Tupelo, Mississippi 38801

United States

Sisters of Saint Mary Health Heart and Vascular Care

Bridgeton, Missouri 63044

United States

Kansas City Veterans Affairs Medical Center

Kansas City, Missouri 64128

United States

Washington University

St Louis, Missouri 63110

United States

Bryan Heart

Lincoln, Nebraska 68506

United States

Physician Research Collaboration, LLC

Lincoln, Nebraska 68516

United States

Excel Clinical Research

Las Vegas, Nevada 89109

United States

American Institute of Medical Research

Las Vegas, Nevada 89123

United States

Las Vegas Clinical Trials

North Las Vegas, Nevada 89030

United States

Renown Institute for Heart and Vascular Health

Reno, Nevada 89502

United States

Advanced Heart Care LLC

Bridgewater, New Jersey 08807

United States

Advanced Heart and Vascular Institute of Hunterdon

Flemington, New Jersey 08822

United States

Clinical Reseach Philadelphia Pennington

Hamilton, New Jersey 08690

United States

Med Clinical Research Partners - Irvington

Irvington, New Jersey 07111

United States

New Jersey Medcare / New Jersey Heart

Linden, New Jersey 07036

United States

Saint Michaels Medical Center

Newark, New Jersey 07102

United States

Circuit Clinical / Optum Medical Care of New Jersey

Secaucus, New Jersey 07094

United States

The Heart House - Washington Township

Sewell, New Jersey 08080

United States

CardioMetabolic Collaborative Clinic

Somerset, New Jersey 08873

United States

Ima Clinical Research - Warren

Warren Township, New Jersey 07059

United States

Albany Medical College

Albany, New York 12203

United States

Basil Clinical

Inwood, New York 11096

United States

Rasai Research

Jackson Heights, New York 11372

United States

Crystal Run Healthcare

Monroe, New York 10950

United States

Icahn School of Medicine at Mount Sinai

New York, New York 10029

United States

Mount Sinai Queens

New York, New York 10029

United States

Ima Clinical Research Manhattan

New York, New York 10036

United States

Niagara Falls Memorial Medical Center

Niagara Falls, New York 14304

United States

Circuit Clinical Orchard Park Family Practice

Orchard Park, New York 14127

United States

Hudson Valley Cardiovascular Physicians PC

Poughkeepsie, New York 12601

United States

Saratoga Clinical Research, LLC

Saratoga Springs, New York 12866

United States

Duke University Health System

Durham, North Carolina 27710

United States

Moses H Cone Memorial Hospital

Greensboro, North Carolina 27401

United States

Medication Management LLC

Greensboro, North Carolina 27405

United States

Triad Clinical Trials, LLC

Greensboro, North Carolina 27410

United States

ClinCept, LLC

Kinston, North Carolina 28501

United States

Monroe Biomedical Research

Monroe, North Carolina 28112

United States

Piedmont Healthcare

Statesville, North Carolina 28625

United States

Accellacare Research of Wilmington

Wilmington, North Carolina 28401

United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina 27157

United States

Lillestol Research LLC

Fargo, North Dakota 58104

United States

Aultman Cardiology Clinical Trials

Canton, Ohio 44710

United States

The Christ Hospital

Cincinnati, Ohio 45219

United States

Velocity Clinical Research - Cincinnati

Cincinnati, Ohio 45219

United States

Nexgen Research

Lima, Ohio 45801

United States

K and R Research

Marion, Ohio 43302

United States

Alliance for Multispecialty Research

Norman, Oklahoma 73069

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

Preferred Primary Care Physicians, Inc

Pittsburgh, Pennsylvania 15236

United States

Pottstown Medical Specialists Inc

Pottstown, Pennsylvania 19464

United States

Miriam Hospital

East Greenwich, Rhode Island 02818

United States

Pharmacorp Clinical Trials Inc

Charleston, South Carolina 29412

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

Prisma Health Carolina Cardiology - Greenville

Gantt, South Carolina 29605

United States

Walker Family Care

Little River, South Carolina 29566

United States

Accellacare Charleston

Mt. Pleasant, South Carolina 29464

United States

Tribe Clinical Research - Spartanburg

Spartanburg, South Carolina 29301

United States

Monument Health Clinical Research

Rapid City, South Dakota 57701

United States

Erlanger Health, Inc.

Chattanooga, Tennessee 37403

United States

Apex Research Foundation, LLC

Jackson, Tennessee 38301

United States

Alliance for Multispecialty Research Knoxville

Knoxville, Tennessee 37909

United States

Ascension Saint Thomas

Nashville, Tennessee 37205

United States

Parkway Cardiology Associates

Oak Ridge, Tennessee 37830

United States

Tennessee Center for Clinical Trials

Tullahoma, Tennessee 37388

United States

PharmaTex Research, LLC

Amarillo, Texas 79106

United States

Texas Diabetes and Endocrinology

Austin, Texas 78731

United States

Ima Clinical Research

Austin, Texas 78745

United States

Pioneer Medical Associates

Carrollton, Texas 75007

United States

Baylor Scott and White Heart and Vascular Hospital-Dallas

Dallas, Texas 75226

United States

Zenos Clinical Research

Dallas, Texas 75230

United States

The Heartbeat Clinic

Dallas, Texas 75243

United States

Cedar Health Research, LLC

Dallas, Texas 75251

United States

Cedar Health Research, LLC

Euless, Texas 76040

United States

East Texas Cardiology PA

Houston, Texas 77002

United States

Baylor College of Medicine

Houston, Texas 77030

United States

Cardiovascular Specialists of Willowbrook

Houston, Texas 77070

United States

Vital Heart and Vein

Humble, Texas 77338

United States

Tcr Institute Llc

Kingwood, Texas 77339

United States

Epic Clinical Research

Lewisville, Texas 75057

United States

Texas Tech University Health Sciences Center

Lubbock, Texas 79430

United States

North Dallas Research Associates

McKinney, Texas 75069

United States

Revival Research Institute

McKinney, Texas 75071

United States

Texas Institute of Cardiology

McKinney, Texas 75071

United States

Southern Endocrinology Associates PA

Mesquite, Texas 75149

United States

Orion Medical

Pasadena, Texas 77505

United States

Valley Institute of Research Plano

Plano, Texas 75024

United States

Ima Clinical Research San Antonio

San Antonio, Texas 78229

United States

St Davids Heart & Vascular PLLC dba Austin Heart

San Marcos, Texas 78666

United States

Tyler Cardiovascular Consultants

Tyler, Texas 75701

United States

Alpine Research Organization

Layton, Utah 84041

United States

Inova Cardiology - Fairfax

Fairfax, Virginia 22031

United States

Virginia Heart

Falls Church, Virginia 22042

United States

Virginia Heart - Loudoun

Leesburg, Virginia 20176

United States

Carient Heart and Vascular

Manassas, Virginia 20109

United States

Bon Secours Cardiology

Midlothian, Virginia 23114

United States

Tidewater Physicians Multispecialty Group Clinical Research

Newport News, Virginia 23606

United States

Alliance for Multispecialty Research Norfolk

Norfolk, Virginia 23502

United States

Centricity Research

Suffolk, Virginia 23435

United States

Selma Medical Associates

Winchester, Virginia 22601

United States

Winchester Medical Center

Winchester, Virginia 22601

United States

Western Washington Medical Group

Everett, Washington 98208

United States

Rainier Clinical Research Center

Renton, Washington 98057

United States

Canberra Hospital

Garran, Australian Capital Territory 2605

Australia

Royal Prince Alfred Hospital

Camperdown, New South Wales 2050

Australia

Novatrials

Charlestown, New South Wales 2290

Australia

Concord Repatriation General Hospital

Concord, New South Wales 2139

Australia

Aim Research

Merewether, New South Wales 2291

Australia

Orange Health Service

Orange, New South Wales 2800

Australia

Wollongong Hospital

Wollongong, New South Wales 2500

Australia

Advara HeartCare Wesley

Auchenflower, Queensland 4066

Australia

Core Research Group Pty Ltd

Milton, Queensland 4064

Australia

University of The Sunshine Coast Clinical Trials, Sippy Downs

Sippy Downs, Queensland 4556

Australia

Dr Heart Pty Ltd

Woolloongabba, Queensland 4102

Australia

Flinders Medical Centre

Bedford Park, South Australia 5042

Australia

Advara HeartCare Leabrook

Leabrook, South Australia 5068

Australia

Fusion Clinical Research

Norwood, South Australia 5067

Australia

Victorian Heart Hospital

Clayton, Victoria 3168

Australia

The Alfred Hospital

Melbourne, Victoria 3004

Australia

Momentum Clinical Research - Sunshine

Melbourne, Victoria 3021

Australia

Clinitrials - Mandurah

Greenfields, Western Australia 6210

Australia

Advara HeartCare Joondalup

Joondalup, Western Australia 6027

Australia

Hollywood Private Hospital

Nedlands, Western Australia 6009

Australia

Linear Clinical Research Limited

Nedlands, Western Australia 6009

Australia

Clinitrials - West Perth

Perth, Western Australia 6000

Australia

Centricity Research Calgary

Calgary, Alberta T2H 2G4

Canada

Edmonton Cardiology Consultants

Edmonton, Alberta T5H 4B9

Canada

Fraser Clinical Trials

New Westminster, British Columbia V3L 3W4

Canada

SMH Cardiology Clinical Trials Incorporated

Surrey, British Columbia V3V 0C6

Canada

ARC Biosystems Incorporated

Vancouver, British Columbia V6Z 1Y6

Canada

Victoria Heart Institute Foundation

Victoria, British Columbia V8R 1B2

Canada

Discovery Clinical Services Ltd

Victoria, British Columbia V8T 5G4

Canada

Centricity Research Brampton

Brampton, Ontario L6S 0C6

Canada

Circulate Cardiac & Vascular Centre

Burlington, Ontario L7M 1K9

Canada

Cambridge Cardiac Care Centre

Cambridge, Ontario N1R 6V6

Canada

Premier Clinical Trial Network

Hamilton, Ontario L8L 5G4

Canada

Elevate Clinical Research KMH Missisauga

Mississauga, Ontario L5K 2L3

Canada

Partners in Advanced Cardiac Evaluation

Newmarket, Ontario L3Y 8C3

Canada

North York Diagnostic and Cardiac Centre

North York, Ontario M6B 3H7

Canada

Oakville Cardiovascular Research

Oakville, Ontario L6K 3W7

Canada

Heart Health Institute Research Incorporated

Scarborough Village, Ontario M1B 4Z8

Canada

Ecogene-21

Chicoutimi, Quebec G7H 7K9

Canada

Montreal Heart Institute

Montreal, Quebec H1T 1C8

Canada

Institut de recherches cliniques de Montreal

Montreal, Quebec H2W 1R7

Canada

Centre de Recherche du Centre Hospitalier de l Universite de Montreal

Montreal, Quebec H2W 1T8

Canada

Research Institute of McGill University Health Center - Glen Site

Montreal, Quebec H4A 3J1

Canada

CIUSSS de l Estrie CHUS Hopital Fleurimont

Sherbrooke, Quebec J1H 5N4

Canada