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NCT07195916PHASE1Recruiting

A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

Incyte Corporation

Start Date

1/8/2026

Completion Date

8/18/2028

Summary

A study to evaluate the safety and tolerability of INCA036873 in participants with advanced solid tumors and hematological malignancies.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Age ≥18 years. * ECOG performance status of 0 or 1. * Histologically confirmed: * Clear cell renal cell carcinoma (ccRCC). * Diffuse large B-cell lymphoma (DLBCL, NOS). * High-grade B-cell lymphoma (HGBCL). * Peripheral T-cell lymphoma (PTCL, incl. NOS and ALCL). * Cutaneous T-cell lymphoma (CTCL, incl. MF or SS ≥Stage IIB with B0/B1 blood involvement). * Disease progression, relapse, or refractory to prior therapy: * ccRCC: ≥1 prior line incl. ICI + TKI. * DLBCL/HGBCL: ≥2 prior lines incl. immunochemotherapy and salvage. * PTCL/CTCL: ≥1 prior systemic therapy. * Measurable disease by RECIST v1.1 (ccRCC), Lugano 2014 (lymphomas), or ISCL/USCLC/EORTC (CTCL). * Tumor tissue available for central testing. Exclusion Criteria: * Untreated or progressive CNS disease unless previously treated and stable. * Other active invasive malignancy within 2 years (except certain low-risk cancers). * Prior CD70-targeting therapy, including CAR T. * ASCT or CAR T ≤12 weeks before enrollment; prior organ or allogeneic transplant. * Unresolved ≥Grade 2 toxicity from prior therapy (with exceptions). * Primary immunodeficiency or active autoimmune disease requiring immunosuppression. * Active HBV, HCV, HIV, or other chronic infections requiring systemic therapy. * Pregnancy, breastfeeding, or unwillingness to use effective contraception. Other protocol-defined Inclusion/Exclusion Criteria may apply.

Interventions

DRUG

INCA036873

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Conditions

Solid TumorsHematologic Malignancies

Locations

City of Hope Medical Center

Duarte, California 91010

United States

University of California San Diego Medical Center, Moores Cancer Center

La Jolla, California 92037

United States

University of Michigan

Ann Arbor, Michigan 48109

United States

The University of Nebraska Medical Center

Omaha, Nebraska 68198

United States

Memorial Sloan Kettering Cancer Center

New York, New York 10021

United States

Scri Oncology Partners

Nashville, Tennessee 37203

United States

Vanderbilt Medical Center

Nashville, Tennessee 37232

United States

Md Anderson Cancer Center

Houston, Texas 77030

United States

Macquarie University Hospital

Sydney, New South Wales 02109

Australia

Princess Alexandra Hospital Australia

Woolloongabba, Queensland 04102

Australia

Cancer Research Sa

Adelaide, South Australia 05000

Australia

Peter Maccallum Cancer Centre-Royal Melbourne Hospital

Melbourne, Victoria 03000

Australia

Cliniques Universitaires Ucl Saint-Luc

Brussels, 01200

Belgium

Universitair Ziekenhuis Antwerpen

Edegem, 02650

Belgium

Universitair Ziekenhuis Gent (Uz Gent)

Ghent, 09000

Belgium

Universitair Ziekenhuis Leuven

Leuven, 03000

Belgium

Aarhus University Hospital

Aarhus, 08200

Denmark

Rigshospitalet Uni of Hospital of Copenhagen

Copenhagen, DK-2100

Denmark

Aou Policlinico S. Orsola-Malpighi

Bologna, 40138

Italy

Fondazione Irccs Istituto Nazionale Dei Tumori

Milan, 20133

Italy

Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore

Rome, 00168

Italy

Centro Ricerche Cliniche Di Verona

Verona, 37134

Italy