A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects
Start Date
2/6/2026
Completion Date
6/1/2029
Summary
The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose levels of cemsidomide in combination with elranatamab in a limited number of subjects. Approximately 3 different dose levels of cemsidomide in combination with elranatamab may be explored. Once a dose level is determined safe, additional subjects may be enrolled through expansion of the dose level. This expansion will provide further exploration of the safety and evaluation of preliminary antimyeloma activity. Cemsidomide will be taken orally each cycle for 14 days on/14 days off (1 cycle=28 days). Elranatamab will be administered by subcutaneous injection twice a month. Dexamethasone will be administered weekly until a confirmed response but no longer than 4 cycles.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Cemsidomide
Elranatamab
Conditions
Locations
Banner MD Anderson Cancer Center
Gilbert, Arizona 85234
United States
UC Davis Comprehensive Cancer Center
Sacramento, California 95817
United States
UCLA Health, Jonsson Comprehensive Cancer Center
Santa Monica, California 90404
United States
University of Florida
Gainesville, Florida 32610
United States
University of Miami
Miami, Florida 33136
United States
Winship Cancer Institute, Emory University
Atlanta, Georgia 30322
United States
Loyola University Medical Center
Maywood, Illinois 60153
United States
Indiana University
Indianapolis, Indiana 46202
United States
Norton Cancer Institute St. Matthews
Louisville, Kentucky 40207
United States
University of Maryland Greenbaum Comprehensive Cancer Center
Baltimore, Maryland 21201
United States
START Midwest
Grand Rapids, Michigan 49546
United States
University of Nebraska
Omaha, Nebraska 68105
United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire 03756
United States
Perlmutter Cancer Center at NYU Langone Hospital
Brooklyn, New York 11203
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10021
United States
Duke Cancer Center
Durham, North Carolina 27710
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Baylor University Medical Center
Dallas, Texas 75246
United States
Houston Methodist Hospital
Houston, Texas 77030
United States
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah 84112
United States