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NCT07501702PHASE2Recruiting

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Vertex Pharmaceuticals Incorporated

Start Date

5/13/2026

Completion Date

3/2/2029

Summary

The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).

Eligibility Criteria

Age Range: 18 years to 80 years

Key Inclusion Criteria: * Age 18-80 years * Diagnosis of generalized myasthenia gravis with generalized muscle weakness and fitting MGFA clinical classification II-IV * Additional inclusion criteria are defined in the protocol Key Exclusion Criteria: * History of thymic surgery within 6 months of screening * History of malignancy within the last 5 years * Additional exclusion criteria are defined in the protocol Other protocol defined Inclusion/Exclusion criteria will apply.

Interventions

DRUG

Povetacicept

DRUG

Placebo

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Conditions

Myasthenia Gravis, Generalized

Locations

Neurology Offices

Boca Raton, Florida 33428

United States

SFM Clinical Reseach, LLC

Boca Raton, Florida 33487

United States

Homestead Associates in Research

Homestead, Florida 33033

United States

UF Health Jacksonville Respiratory Therapy (PFT and DLCO)

Jacksonville, Florida 32209

United States

Y & L Advance Health Care, Inc D/B/A Elite Clinical Research - Neurology

Miami, Florida 33144

United States

Quantix Research

Miami, Florida 33173

United States

Hawaii Pacific Neuroscience

Honolulu, Hawaii 96817

United States

HSHS Medical Group - St. Elizabeth's Hospital

O'Fallon, Illinois 62269

United States

Las Vegas Neurology Center

Las Vegas, Nevada 89106

United States

Clinical Trials of South Carolina - Neurology

Charleston, South Carolina 29406

United States

Ut Erlanger Neurology

Chattanooga, Tennessee 37403

United States

Nerve and Muscle Center of Texas - Neurology

Houston, Texas 77030

United States

Texas Institute for Neurological Disorders

Sherman, Texas 75093

United States

Neurology Care Clinic

Waxahachie, Texas 75165

United States

Eastern Health - Box Hill Hospital

Box Hill,

Australia

MICS Centrum Medyczne Bydgoszcz

Bydgoszcz,

Poland

Neurologia Slaska Centrum Medyczne

Katowice,

Poland

Clinical Research Center Sp. z o.o., Medic-R Sp. K.

Poznan,

Poland

NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partnerska Lekarzy

Poznan,

Poland

Centrum Medyczne Neuroprotect

Warsaw,

Poland

ETG Neuroscience

Warsaw,

Poland

University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital

Birmingham,

United Kingdom

St. George's University Hospital

London,

United Kingdom

Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital

Salford,

United Kingdom