Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
Start Date
6/1/2026
Completion Date
2/1/2029
Summary
The purpose of this study is to evaluate the safety and efficacy of atebimetinib in combination with modified GnP compared with SOC GnP alone.
Detailed Description
This is a global, randomized, open-label, Phase 3 study designed to evaluate whether treatment with atebimetinib plus a modified schedule of gemcitabine and nab-paclitaxel will improve overall survival compared with standard gemcitabine and nab-paclitaxel when given as first-line treatment in patients with metastatic pancreatic adenocarcinoma. Patients will be randomized to one of two arms: Arm A with atebimetinib + gemcitabine and nab-paclitaxel (modified dosing schedule) or Arm B with gemcitabine and nab-paclitaxel.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Atebimetinib
GnP
mGnP
Conditions
Locations
City of Hope
Phoenix, Arizona 85338
United States
City of Hope
Duarte, California 91010
United States
Medical Oncology Hematology Consultants
Newark, Delaware 19713
United States
Hematology Oncology Associates of the Treasure Coast
Port Saint Lucie, Florida 34952
United States
Florida Cancer Specialists - South
Sarasota, Florida 34239
United States
Florida Cancer Specialists - North
St. Petersburg, Florida 33701
United States
Florida Cancer Specialists - East
West Palm Beach, Florida 33401
United States
Piedmont Healthcare
Atlanta, Georgia 30318
United States
Illinois Cancer Specialists
Arlington Heights, Illinois 60005
United States
City of Hope
Chicago, Illinois 60099
United States
OSF Medical Center
Peoria, Illinois 61603
United States
Maryland Oncology
Columbia, Maryland 21044
United States
Missouri Cancer Associates
Columbia, Missouri 65201
United States
Comprehensive Cancer Centers
Las Vegas, Nevada 89169
United States
Regional Cancer Care
Belleville, New Jersey 07109
United States
NYU Langone Health
New York, New York 10016
United States
Taylor Cancer Research Center
Maumee, Ohio 43537
United States
Willamette Valley Cancer Institute
Eugene, Oregon 97401
United States
Thomas Jefferson University
Philadelphia, Pennsylvania 19107
United States
West Cancer Center
Germantown, Tennessee 38138
United States
Sarah Cannon Research Institute
Nashville, Tennessee 37203
United States
Texas Oncology - West Texas
Abilene, Texas 79606
United States
Texas Oncology - Austin
Austin, Texas 78705
United States
Texas Oncology - San Antonio
San Antonio, Texas 78240
United States
Texas Oncology Gulf Coast
Webster, Texas 77598
United States
Blue Ridge Cancer Care
Blacksburg, Virginia 24060
United States
Virginia Cancer Specialists
Fairfax, Virginia 22031
United States
Northwest Cancer Specialists
Vancouver, Washington 98684
United States
Calvary Mater Newcastle
Waratah, New South Wales 2298
Australia
Genesiscare
Waratah, New South Wales 2298
Australia
Icon Cancer Centre - Chermside
Chermside, Queensland 4032
Australia