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NCT07639021PHASE2Recruiting

A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

Novo Nordisk A/S

Start Date

6/9/2026

Completion Date

7/12/2027

Summary

The purpose of the study is to find out if NNC0662-0419 is safe and effective for treating participants living with obesity.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18 years or above at the time of signing the informed consent. * Body mass index (BMI) greater than or equal to (≥) 30.0 kilogram per square meter (kg/m\^2) at screening. * Participant must have a desire and be committed to lose at least 25 percentage (%) of their body weight from randomisation. Exclusion Criteria: * Known or suspected hypersensitivity to study intervention(s) or related products. * Treatment with any medication prescribed for the indication of obesity or weight management (e.g. glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues)) within 90 days before screening. * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 Millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus.

Interventions

DRUG

NNC0662-0419

DRUG

Semaglutide

DRUG

NNC0662-0419 Placebo

DRUG

Semaglutide placebo

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Conditions

Obesity

Locations

Chambliss Clinical Trials, LLC

Montgomery, Alabama 36106

United States

FDRC

Costa Mesa, California 92627

United States

Los Angeles Institute for Metabolic Research

Los Angeles, California 90015

United States

Encore Medical Research LLC

Hollywood, Florida 33024

United States

South Broward Research LLC

Miramar, Florida 33027

United States

West Orange Endocrinology

Ocoee, Florida 34761

United States

Cedar-Crosse Research Center

Chicago, Illinois 60607

United States

Great Lakes Clinical Trials

Chicago, Illinois 60640

United States

Midwest Inst For Clin Res

Indianapolis, Indiana 46260

United States

L-MARC Research Center

Louisville, Kentucky 40213

United States

Endo And Metab Cons

Rockville, Maryland 20852

United States

StudyMetrix Research LLC

City of Saint Peters, Missouri 63303

United States

Great Lakes Medical Research

Westfield, New York 14787

United States

KDCILM, LLC & Accellacare US, Inc.

Wilmington, North Carolina 28401

United States

Family Practice Center of Wadsworth Inc.

Wadsworth, Ohio 44281-9236

United States

UPA Ctr Weight and Eating Dis

Philadelphia, Pennsylvania 19104

United States

Clinical Res Collaborative

Cumberland, Rhode Island 02864

United States

Holston Medical Group_Bristol

Bristol, Tennessee 37620

United States

Holston Medical Group

Kingsport, Tennessee 37660

United States

Clinical Research Associates

Nashville, Tennessee 37203

United States

PlanIt Research, PLLC

Houston, Texas 77079

United States

Pinnacle Clinical Research

San Antonio, Texas 78222

United States

National Clin Res Inc.

Richmond, Virginia 23294

United States

Rainier Clin Res Ctr Inc

Renton, Washington 98057

United States

Isis Clinical Res. Ctr P.S.C.

Guaynabo, 00968

Puerto Rico