Back to Trials
NCT07662135PHASE3Recruiting

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin

AstraZeneca

Start Date

7/6/2026

Completion Date

7/13/2028

Summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background of sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin 10 mg as per guideline directed medical therapy (GDMT) for chronic kidney disease (CKD). Additionally, participants are on other glucose-lowering medication(s).

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus for at least 90 days prior to screening * On SGTL2i or SGLT2i-naïve and other glucose lowering medication(s) * HbA1c value: 1. On stable dose of SGLT2i ≥ 7.0 % to ≤ 10.5% (53 to 91.3 mmol/mol) 2. SGLT2i-naive ≥ 7.5% to ≤ 10.5% (58 to 91.3 mmol/mol) * Impaired renal function * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 Diabetes, secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper GI tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (New York Heart Association IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

Interventions

DRUG

Elecoglipron

DRUG

Placebo

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Type 2 Diabetes MellitusType 2 Diabetes With Chronic Kidney Disease

Locations

Research Site

Peoria, Arizona 85382

United States

Research Site

Surprise, Arizona 85374

United States

Research Site

Concord, California 94520

United States

Research Site

Sacramento, California 95821

United States

Research Site

Victorville, California 92392

United States

Research Site

Fleming Island, Florida 32003

United States

Research Site

Lauderdale Lakes, Florida 33313

United States

Research Site

Leesburg, Florida 34748

United States

Research Site

Miami Lakes, Florida 33016

United States

Research Site

Ocoee, Florida 34761

United States

Research Site

Orlando, Florida 32804

United States

Research Site

Braintree, Massachusetts 02184

United States

Research Site

New Bedford, Massachusetts 02740

United States

Research Site

Saint Joseph, Michigan 49085

United States

Research Site

Saint Paul, Minnesota 55117

United States

Research Site

Kansas City, Missouri 64111

United States

Research Site

Omaha, Nebraska 68144

United States

Research Site

Las Vegas, Nevada 89119

United States

Research Site

Albuquerque, New Mexico 87102

United States

Research Site

The Bronx, New York 10451

United States

Research Site

Kinston, North Carolina 28504

United States

Research Site

Raleigh, North Carolina 27609

United States

Research Site

Winston-Salem, North Carolina 27103

United States

Research Site

Cincinnati, Ohio 45219

United States

Research Site

East Providence, Rhode Island 02914

United States

Research Site

Gaffney, South Carolina 29340

United States

Research Site

Greenville, South Carolina 29605

United States

Research Site

San Antonio, Texas 78257

United States

Research Site

Ogden, Utah 84405

United States

Research Site

Arlington, Virginia 22205

United States

Research Site

Rousse, 7000

Bulgaria

Research Site

Binzhou, 256606

China

Research Site

Changsha, 430033

China

Research Site

Chengdu, 610081

China

Research Site

Hangzhou, 310006

China

Research Site

Jinan, 250013

China

Research Site

Liaocheng, 252000

China

Research Site

Liuzhou, 545006

China

Research Site

Luoyang, 471003

China

Research Site

Nanjing, 211100

China

Research Site

Nanyang, 473000

China

Research Site

Suining Shi, 629000

China

Research Site

Yibin, 610500

China

Research Site

Yichang, 443003

China

Research Site

Zhengzhou, 450002

China

Research Site

Zhengzhou, 450012

China

Research Site

Aarhus N, 8200

Denmark

Research Site

Gistrup, 9260

Denmark

Research Site

Herlev, 2730

Denmark

Research Site

Hillerød, 3400

Denmark

Research Site

Holbæk, 4300

Denmark

Research Site

Hvidovre, 2650

Denmark

Research Site

Bad Oeynhausen, 32545

Germany

Research Site

Berlin, 12047

Germany

Research Site

Brandenburg an der Havel, 14776

Germany

Research Site

Chemnitz, 09116

Germany

Research Site

Duisburg, 47051

Germany

Research Site

Duisburg, 47269

Germany

Research Site

Erlangen, 91054

Germany

Research Site

Frankfurt, 60596

Germany

Research Site

Hamburg, 22607

Germany

Research Site

Heilbronn, 74076

Germany

Research Site

Hohenmölsen, 06679

Germany

Research Site

Ludwigshafen, 67059

Germany

Research Site

Münster, 48153

Germany

Research Site

Nittendorf, 93152

Germany

Research Site

Obertshausen, 63179

Germany

Research Site

Pirna, 01796

Germany

Research Site

Sankt Ingbert, 66386

Germany

Research Site

Stuttgart, 70174

Germany

Research Site

Aligarh, 202002

India

Research Site

Belagavi, 590006

India

Research Site

Belgavi, 590010

India

Research Site

Chennai, 600037

India

Research Site

Chennai, 600086

India

Research Site

Coimbatore, 641018

India

Research Site

Delhi, 110029

India

Research Site

Guntur, 522001

India

Research Site

Kolkata, 700020

India

Research Site

Lucknow, 226030

India

Research Site

Nagpur, 440010

India

Research Site

Pune, 411021

India

Research Site

Chigasaki-shi, 253-0044

Japan

Research Site

Chikushino-shi, 8188502

Japan

Research Site

Gifu, 501-1194

Japan

Research Site

Kitakyushu, 805-8508

Japan

Research Site

Kumamoto, 862-0965

Japan

Research Site

Kyoto, 605-0981

Japan

Research Site

Kyoto, 606-8507

Japan

Research Site

Maebashi, 371-8511

Japan

Research Site

Nagoya, 468-0009

Japan

Research Site

Osaka, 559-0012

Japan

Research Site

Sapporo, 060-0062

Japan

Research Site

Toyota-Shi, 471-8513

Japan

Research Site

Batu Caves, 68100

Malaysia

Research Site

Kuala Lumpur, 59100

Malaysia

Research Site

Miri, 98000

Malaysia

Research Site

Seremban, 70300

Malaysia

Research Site

Seri Manjung, 32040

Malaysia

Research Site

Chihuahua City, 31238

Mexico

Research Site

Cuernavaca, 62250

Mexico

Research Site

Cuernavaca, 62448

Mexico

Research Site

Guadalajara, 44600

Mexico

Research Site

Guadalajara, 44670

Mexico

Research Site

Mexico City, 0 3100

Mexico

Research Site

Monterrey, 64030

Mexico

Research Site

Monterrey, 64460

Mexico

Research Site

Zapopan, 45116

Mexico

Research Site

Barcelona, 08035

Spain

Research Site

Ferrol, 15405

Spain

Research Site

Lleida, 25198

Spain

Research Site

Madrid, 28040

Spain

Research Site

Majadahonda, 28222

Spain

Research Site

Málaga, 29010

Spain

Research Site

Santander, 39008

Spain

Research Site

Seville, 41010

Spain

Research Site

Seville, 41013

Spain

Research Site

Seville, 41950

Spain

Research Site

Valencia, 46010

Spain

Research Site

Zaragoza, 50009

Spain

Research Site

Kaohsiung City, 833401

Taiwan

Research Site

New Taipei City, 23561

Taiwan

Research Site

New Taipei City,

Taiwan

Research Site

Taichung, 40447

Taiwan

Research Site

Taichung, 40705

Taiwan

Research Site

Taichung, 433004

Taiwan

Research Site

Tainan, 710

Taiwan

Research Site

Taipei, 100

Taiwan

Research Site

Taipei, 110

Taiwan

Research Site

Taoyuan, 333

Taiwan

Research Site

Zhubei, 302

Taiwan

Research Site

Bangkok, 10210

Thailand

Research Site

Bangkok, 10700

Thailand

Research Site

Chiang Mai, 50200

Thailand

Research Site

Hat Yai, 90110

Thailand

Research Site

Muang, 70000

Thailand

Research Site

Ratchathewi, 10400

Thailand

Research Site

Adana, 01060

Turkey (Türkiye)

Research Site

Ankara, 06530

Turkey (Türkiye)

Research Site

Antalya, 07070

Turkey (Türkiye)

Research Site

Bakırköy, 34147

Turkey (Türkiye)

Research Site

Gaziantep, 27470

Turkey (Türkiye)

Research Site

Kayseri, 38039

Turkey (Türkiye)

Research Site

Kayseri, 38080

Turkey (Türkiye)

Research Site

Yüreğir, 1240

Turkey (Türkiye)

Research Site

Kyiv, 01601

Ukraine

Research Site

Kyiv, 02002

Ukraine

Research Site

Kyiv, 03037

Ukraine

Research Site

Kyiv, 03049

Ukraine

Research Site

Kyiv, 03057

Ukraine

Research Site

Kyiv, 04050

Ukraine

Research Site

Kyiv, 04210

Ukraine

Research Site

Lviv, 79010

Ukraine

Research Site

Lviv, 79016

Ukraine

Research Site

Vinnytsia, 21029

Ukraine

Research Site

Blackpool, FY3 7EN

United Kingdom

Research Site

Glasgow, G4 0SF

United Kingdom

Research Site

Hull, HU3 2JZ

United Kingdom

Research Site

Penzance, TR18 3DX

United Kingdom

Research Site

Sandbach, CW11 1EQ

United Kingdom

Research Site

Thetford, IP24 1JD

United Kingdom

Research Site

Whitney, OX29 4QB

United Kingdom

Research Site

Haiphong, 180000

Vietnam

Research Site

Hanoi, 100000

Vietnam

Research Site

Hanoi, 10000

Vietnam

Research Site

Hà Nội, 100000

Vietnam

Research Site

Ho Chi Minh City, 700000

Vietnam

Research Site

Hochiminh City, 700000

Vietnam

Research Site

Viet Tri, 35000

Vietnam