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NCT07720271PHASE3Recruiting

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

Novo Nordisk A/S

Start Date

8/31/2026

Completion Date

8/22/2028

Summary

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Male or female (sex at birth). * Age 18 and older (both inclusive) at time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

Interventions

DRUG

zenagamtide

DRUG

Placebo

Interested in This Trial?

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Conditions

OverweightObesity

Locations

Pinnacle Research Group LLC

Anniston, Alabama 36207

United States

Univ of Alabama Birmingham

Birmingham, Alabama 35294

United States

Chambliss Clinical Trials LLC

Montgomery, Alabama 36106

United States

Providence Medical Foundation

Fullerton, California 92835

United States

Torrance Clinical Research Institute, Inc.

Lomita, California 90717

United States

Diablo Clinical Research, Inc.

Walnut Creek, California 94598

United States

Univ of Colorado at Denver

Aurora, Colorado 80045

United States

Brain Matters Research

Delray Beach, Florida 33445

United States

Northeast Research Institute

Fleming Island, Florida 32003

United States

Miguel Rebollar PA

Hialeah, Florida 33012

United States

Jacksonville Ctr Clin Res

Jacksonville, Florida 32216

United States

South Broward Research LLC

Miramar, Florida 33027

United States

Clinical Neuroscience Solution

Orlando, Florida 32801

United States

Florida Institute for Clinical Research, LLC

Orlando, Florida 32825

United States

Oviedo Medical Research, LLC

Oviedo, Florida 32765

United States

Hope Clin Res & Wellness

Conyers, Georgia 30094

United States

East West Medical Research Institute_Honolulu

Honolulu, Hawaii 96814

United States

Great Lakes Clinical Trials

Chicago, Illinois 60640

United States

Clinical Investigation Spec Gurnee

Gurnee, Illinois 60031

United States

Endeavor Health

Skokie, Illinois 60077

United States

Evanston Premier Hlthcr Res

Skokie, Illinois 60077

United States

Midwest Inst For Clin Res

Indianapolis, Indiana 46260

United States

Northern Pines Hlth Ctr, PC

Buckley, Michigan 49620

United States

StudyMetrix Research LLC

City of Saint Peters, Missouri 63303

United States

Palm Research Center Inc.

Las Vegas, Nevada 89128

United States

Comprehensive Weight Ctrl Prog

New York, New York 10021

United States

Medication Mgmnt, LLC_Grnsboro

Greensboro, North Carolina 27401

United States

Accellacare of Raleigh

Raleigh, North Carolina 27609

United States

Accellacare-Salisbury PMG Res

Salisbury, North Carolina 28144

United States

Accellacare and KDCILM, LLC

Wilmington, North Carolina 28401

United States

Lynn Institute of Norman

Norman, Oklahoma 73072

United States

Clinical Res Collaborative

Cumberland, Rhode Island 02864

United States

Medical Uni of SC Charleston

Charleston, South Carolina 29425

United States

Coastal Carolina Research Ctr

North Charleston, South Carolina 29405

United States

Hillcrest Clinical Research

Simpsonville, South Carolina 29681-1538

United States

Spartanburg Medical Research

Spartanburg, South Carolina 29303

United States

Amarillo Medical Specialists

Amarillo, Texas 79124

United States

North Texas Endocrine Center

Dallas, Texas 75231

United States

Washington Cntr Weight Mgmt

Arlington, Virginia 22206

United States

Health Res of Hampton Roads

Newport News, Virginia 23606

United States

National Clin Res Inc.

Richmond, Virginia 23294

United States