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NCT07745504PHASE3Recruiting

A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight

Novo Nordisk A/S

Start Date

8/4/2026

Completion Date

7/6/2027

Summary

The purpose of this clinical study is to look at how well a study medicine called cagrilintide helps people living with excess body weight to lose weight. Participants will either get cagrilintide, the active study medicine being tested or placebo, a medicine that has no active medicine in it. Which treatment participants get is decided by chance. Cagrilintide is a new medicine under development that doctors cannot prescribe yet, but it has been tested in humans before. Participants will be in this clinical study for about 9 months.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion criteria: * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18 years or above at the time of signing the informed consent. * Body mass index (BMI) greater than or equal to (\>=) 30.0 kilograms per square meter (kg/m\^2), or BMI \>= 27.0 kg/m\^2 with the presence of at least one weight related comorbidity including, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease. Exclusion criteria: * History of Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D). * Previous dosing of marketed or non-marketed amylin-based compounds. * Treatment, or intention to initiate treatment, with any medication prescribed for the indication of weight management within 180 days before screening.

Interventions

DRUG

Cagrilintide

DRUG

Placebo cagrilintide

DRUG

Placebo semaglutide

Interested in This Trial?

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Conditions

OverweightObesity

Locations

Hope Clin Res & Wellness

Conyers, Georgia 30094

United States

East West Med Res Inst

Honolulu, Hawaii 96814

United States

Walgreens - Store 11760

Oak Park, Illinois 60302

United States

Midwest Inst For Clin Res

Indianapolis, Indiana 46260

United States

The Alliance for Multispecialty Research LLC AMR

Lexington, Kentucky 40509

United States

PharmQuest

Greensboro, North Carolina 27408

United States

KDCILM, LLC & Accellacare US, Inc.

Wilmington, North Carolina 28401

United States

Coastal Carolina Res Ctr

North Charleston, South Carolina 29405

United States

Health Res of Hampton Roads

Newport News, Virginia 23606

United States

National Clin Res Inc.

Richmond, Virginia 23294

United States

Selma Medical Associates

Winchester, Virginia 22601-3834

United States

General Hospital Of Athens Alexandra - Department of Endocrinology, Diabetes Center

Athens, 115 28

Greece

General Hospital Of Athens G Gennimatas - Department of Endocrinology

Athens, 11527

Greece

General Hospital Venizeleio-Pananeio - Diabetic Clinic

Irakleio, 71409

Greece

Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department

Peristeri, 121 31

Greece

Ippokratio General Hospital Of Thessaloniki - B' Internal Medicine clinic

Thessaloniki, 546 42

Greece

St. Luke's Hospital S.A. - Endocrinology Department and Obesity Clinic

Thessaloniki, 552 36

Greece

Stúdium Egészségház Kft.

Kalocsa, Bács-Kiskun county 6300

Hungary

Borbánya Praxis E.Ü. Kft.

Nyíregyháza, Szabolcs-Szatmar Varmegye 4405

Hungary

Trial Pharma Kft.

Kecskemét, 6000

Hungary

KomplexLabor Diagnosztika Kft.

Szeged, 6724

Hungary

ULS Do Oeste E.P.E. - Unidade Caldas da Rainha_CAMI - Unidade de Diabetes

Caldas da Rainha, 2500-176

Portugal

ULS Do Baixo Mondego, E.P.E. - HDFF_Serviço Cirurgia (Esp. Endocrinologia)

Figueira da Foz Municipality, 3094-001

Portugal

Hospital São Francisco, S.A_EECC

Leiria, 2400-110

Portugal

APDP - Associação Protectora dos Diabéticos de Portugal

Lisbon, 1250-189

Portugal

CVP Hospital Cruz Vermelha_Cardiologia

Lisbon, 1549-008

Portugal

ULS De Gaia/Espinho_H.Santos Silva_Endocrinologia

Vila Nova de Gaia, 4434-502

Portugal

Endocrinology, Diabetes and Metabolism Diseases Clinic

Belgrade, 11000

Serbia

Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica

Kamenitz, 21204

Serbia

Clinical Centre Nis, Endocrinology, Diabetes and Metabolism

Niš, 18000

Serbia

University Clinical Centre Nis, Clinic for Cardiology

Niš, 18108

Serbia

Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.

Novi Sad, 21000

Serbia

Skånes Universitets Sjukhus

Lund, 222 42

Sweden

Forsåker vårdcentral

Mölndal, 431 33

Sweden

Örebro US - Överviktsenheten

Örebro, 701 85

Sweden

Dalecarlia Clinical Research AB

Rättvik, 795 30

Sweden