A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Start Date
9/20/2022
Completion Date
11/30/2033
Summary
The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
mezigdomide
Pomalidomide
Bortezomib
Dexamethasone
Conditions
Locations
Local Institution - 0366
Los Alamitos, California 90720
United States
Local Institution - 0272
San Diego, California 92123
United States
Local Institution - 0273
West Hollywood, California 90069
United States
Local Institution - 0381
Aurora, Colorado 80045
United States
Local Institution - 0380
Farmington, Connecticut 06030
United States
Local Institution - 0208
New Haven, Connecticut 06510
United States
Local Institution - 0303
Coral Springs, Florida 33321
United States
Local Institution - 0403
Fort Myers, Florida 33901
United States
Local Institution - 0401
St. Petersburg, Florida 33701
United States
Local Institution - 0402
West Palm Beach, Florida 33401
United States
Local Institution - 0211
Athens, Georgia 30607
United States
Local Institution - 0048
Marietta, Georgia 30060
United States
Local Institution - 0330
Garden City, Kansas 67846
United States
Local Institution - 0080
Westwood, Kansas 66205
United States
Local Institution - 0358
Baton Rouge, Louisiana 70808
United States
Local Institution - 0255
New Orleans, Louisiana 70112
United States
Local Institution - 0385
Shreveport, Louisiana 71103
United States
Local Institution - 0357
Baltimore, Maryland 21215
United States
Local Institution - 0246
Boston, Massachusetts 02215
United States
Local Institution - 0271
Ann Arbor, Michigan 48109
United States
Local Institution - 0364
Detroit, Michigan 48202
United States
Local Institution - 0410
Minneapolis, Minnesota 55404
United States
Local Institution - 0088
Hattiesburg, Mississippi 39401
United States
Local Institution - 0242
Jackson, Mississippi 39213
United States
Local Institution - 0288
East Brunswick, New Jersey 08816
United States
Local Institution - 0363
Ridgewood, New Jersey 07450
United States
Local Institution - 0302
Albuquerque, New Mexico 87131
United States
Local Institution - 0245
Buffalo, New York 14215
United States
Local Institution - 0257
Lake Success, New York 11042
United States
Local Institution - 0373
New Hyde Park, New York 11042
United States
Local Institution - 0371
New York, New York 10028
United States
Local Institution - 0108
Rochester, New York 14621
United States
Local Institution - 0374
Shirley, New York 11967
United States
Local Institution - 0372
The Bronx, New York 10469
United States
Local Institution - 0274
Williamsville, New York 14221
United States
Local Institution - 0260
Durham, North Carolina 27710
United States
Local Institution - 0400
Cincinnati, Ohio 45242
United States
Local Institution - 0377
Cleveland, Ohio 44111
United States
Local Institution - 0076
Cleveland, Ohio 44195
United States
Local Institution - 0376
Mayfield Heights, Ohio 44124
United States
Local Institution - 0359
Allentown, Pennsylvania 18103
United States
Local Institution - 0264
York, Pennsylvania 17403
United States
Local Institution - 0223
Germantown, Tennessee 38138
United States
Local Institution - 0378
Abilene, Texas 79606
United States
Local Institution - 0275
Houston, Texas 77030
United States
Local Institution - 0267
San Antonio, Texas 78229
United States
Local Institution - 0409
San Antonio, Texas 78240
United States
Local Institution - 0207
Salt Lake City, Utah 84106
United States
Local Institution - 0297
Fredericksburg, Virginia 22408
United States
Local Institution - 0408
Norfolk, Virginia 23502
United States
Local Institution - 0399
Roanoke, Virginia 24014
United States
Local Institution - 0268
Seattle, Washington 98108
United States
Local Institution - 0293
Seattle, Washington 98109
United States
Local Institution - 0097
Spokane, Washington 99208
United States
Local Institution - 0411
Vancouver, Washington 98684
United States
Local Institution - 0220
Madison, Wisconsin 53792
United States
Local Institution - 0318
Chivilcoy, Buenos Aires 6620
Argentina
Local Institution - 0213
Buenos Aires, Buenos Aires F.D. 1425
Argentina
Local Institution - 0249
Córdoba, Córdoba Province 5016
Argentina
Local Institution - 0239
Viedma, R R8500ACE
Argentina
Local Institution - 0200
Rosario, Santa Fe Province 2000
Argentina
Local Institution - 0248
S3000epv, Santa Fe Province 3000
Argentina
Local Institution - 0214
Buenos Aires, CP1280AEB
Argentina
Local Institution - 0055
Liverpool, New South Wales 2170
Australia
Local Institution - 0004
Waratah, New South Wales 2298
Australia
Local Institution - 0017
Wollongong, New South Wales 2500
Australia
Local Institution - 0327
Birtinya, Queensland 4575
Australia
Local Institution - 0221
Box Hill, Victoria 3128
Australia
Local Institution - 0003
Melbourne, Victoria 3004
Australia
Local Institution - 0002
Melbourne, Victoria 3065
Australia
Local Institution - 0040
Nedlands, Western Australia 6009
Australia
Local Institution - 0012
Vienna, State of Vienna 1160
Austria
Local Institution - 0008
Krems, 3500
Austria
Local Institution - 0024
Leoben, 8700
Austria
Local Institution - 0011
Sankt Pölten, 3100
Austria
Local Institution - 0025
Vienna, 1140
Austria
Ziekenhuis Oost-Limburg, Campus St.-Jan
Genk, Limburg 3600
Belgium
UZ Gent
Ghent, Oost-Vlaanderen 9000
Belgium
AZ Nikolaas
Sint-Niklaas, Oost-Vlaanderen B-9100
Belgium
ZNA Cadix
Antwerp, 2030
Belgium
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Salvador, Estado de Bahia 40301-155
Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
Porto Alegre, Rio Grande do Sul 90110-270
Brazil
Instituto Joinvilense de Hematologia e Oncologia
Joinville, Santa Catarina 89202-050
Brazil
Hospital Amaral Carvalho
Jaú, São Paulo 17210-080
Brazil
Americas Centro de Oncologia Integrado
Rio de Janeiro, 22793080
Brazil
Clínica Médica São Germano S/S Ltda
São Paulo, 04537-080
Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05652-900
Brazil
Local Institution - 0225
Greenfield Park, Quebec J4V 2H1
Canada
Local Institution - 0174
Montreal, Quebec H4J 1C5
Canada
Local Institution - 0222
Québec, Quebec G1J 1Z4
Canada
Local Institution - 0329
Santiago, Santiago Metropolitan 7580206
Chile
Local Institution - 0387
Santiago, Santiago Metropolitan 8420383
Chile
Local Institution - 0332
Viña del Mar, Valparaiso 0
Chile
Local Institution - 0062
Beijing, Beijing Municipality 100043
China
Local Institution - 0165
Beijing, Beijing Municipality 100043
China
Local Institution - 0141
Beijing, Beijing Municipality 100091
China
Local Institution - 0144
Chongqing, Chongqing Municipality 400016
China
Local Institution - 0237
Xiamen, Fujian 361003
China
Local Institution - 0117
Guangzhou, Guangdong 450008
China
Local Institution - 0177
Guangzhou, Guangdong 510060
China
Local Institution - 0168
Guangzhou, Guangdong 510080
China
Local Institution - 0238
Shenzhen, Guangdong 518039
China
Local Institution - 0412
Liuzhou, Guangxi 0
China
Local Institution - 0240
Nanning, Guangxi 530007
China
Local Institution - 0254
Shijiazhuang, Hebei 50000
China
Local Institution - 0395
Luoyang, Henan 471003
China
Local Institution - 0113
Zhengzhou, Henan 450003
China
Local Institution - 0142
Wuhan, Hubei 430022
China
Local Institution - 0155
Changsha, Hunan 410008
China
Local Institution - 0147
Changsha, Hunan 410013
China
Local Institution - 0111
Nanjing, Jiangsu 210000
China
Local Institution - 0139
Wuxi, Jiangsu 214023
China
Local Institution - 0287
Shenyang, Liaoning 110004
China
Local Institution - 0148
Xi'an, Shaanxi 710004
China
Local Institution - 0110
Xi'an, Shaanxi 710126
China
Local Institution - 0169
Qingdao, Shandong 266000
China
Local Institution - 0114
Shanghai, Shanghai Municipality 200030
China
Local Institution - 0350
Shanghai, Shanghai Municipality 200434
China
Local Institution - 0164
Taiyuan, Shanxi 030001
China
Local Institution - 0356
Deyang, Sichuan 618000
China
Local Institution - 0119
Tianjin, Tianjin Municipality 300060
China
Local Institution - 0353
Ürümqi, Xinjiang 830001
China
Local Institution - 0202
Kunming, Yunnan 650032
China
Local Institution - 0151
Hangzhou, Zhejiang 310003
China
Local Institution - 0348
Linhai, Zhejiang 317000
China
Local Institution - 0112
Ningbo, Zhejiang 315010
China
Local Institution - 0149
Wenzhou, Zhejiang 32500
China
Local Institution - 0150
Beijing, 100034
China
Local Institution - 0176
Taiyuan, 030032
China
Local Institution - 0037
Brno, Brno-město 625 00
Czechia
Local Institution - 0383
Prague, Praha 10 100 34
Czechia
Local Institution - 0039
Prague, 12808
Czechia
Local Institution - 0256
Kuopio, Northern Savonia 70210
Finland
Local Institution - 0072
Helsinki, 00029
Finland
Institut de cancérologie Strasbourg Europe (ICANS)
Strasbourg, Alsace 67033
France
Local Institution - 0091
Pessac, Aquitaine 33600
France
Centre Leon Berard
Lyon Cedex08, Auvergne-Rhône-Alpes 69373
France
Hopital Claude Huriez - CHU de Lille
Lille, Nord 59000
France
Centre Hospitalier Universitaire Estaing
Clermont-Ferrand, 63100
France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
Limoges, 87042
France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
Nantes, 44093
France
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau
Nîmes, 30029
France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, 37032
France
Hôpital Saint Antoine
Paris, Île-de-France Region 75571
France
TUM Klinikum
München, Bavaria 81675
Germany
Klinikum Traunstein
Traunstein, Bavaria 83278
Germany
Medizinisches Versorgungszentrum
Weiden, Bavaria 92367
Germany
Universitaetsklinik Marburg
Marburg, Hesse 35033
Germany
Praxis Onkologie am Raschplatz
Hanover, Lower Saxony 30161
Germany
Universitätsklinikum Bonn
Bonn, North Rhine-Westphalia 53127
Germany
Marien Hospital Düsseldorf
Düsseldorf, North Rhine-Westphalia 40479
Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, Schleswig-Holstein 24105
Germany
Local Institution - 0396
Erfurt, Thuringia 99085
Germany
Universitätsklinikum Aachen
Aachen, 52074
Germany
Sozialstiftung Bamberg
Bamberg, 96049
Germany
Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf
Dresden, 01307
Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, 20251
Germany
Asklepios Altona
Hamburg, 22763
Germany
Universitaetsklinikum Tuebingen
Tübingen, 72076
Germany
Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher
Würzburg, 97080
Germany
Local Institution - 0190
Athens, Attikí 106 76
Greece
Local Institution - 0191
Athens, Attikí 115 28
Greece
G. Papanikolaou General Hospital
Thessaloniki, Thessaloníki 570 10
Greece
HCG Aastha Cancer Centre
Ahmedabad, Gujarat 380060
India
Marengo Asia Hospitals Gurugram
Gurugram, Haryana 122011
India
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, Karnataka 590010
India
Mumbai Oncocare Centre - Nanachowk
Mumbai, Maharashtra 400036
India
Local Institution - 0344
Madurai, Tamil Nadu 625107
India
Local Institution - 0341
Varanasi, Uttar Pradesh 221002
India
Christian Medical College & Hospital
Ludhiana, 141008
India
Jawaharlal Institute Of Postgraduate Medical Education And Research
Puducherry, 605006
India
Local Institution - 0121
Galway, Connacht H91 YR71
Ireland
Local Institution - 0122
Cork, T12 E8YV
Ireland
Local Institution - 0120
Dublin, D08 E9P6
Ireland
Local Institution - 0251
Limerick, V94 F858
Ireland
Local Institution - 0196
Kfar Saba, Central District 4428164
Israel
Local Institution - 0195
Ramat Gan, Central District 5262100
Israel
Local Institution - 0197
Jerusalem, Jerusalem 91220
Israel
Local Institution - 0192
Haifa, Northern District 3109601
Israel
Local Institution - 0193
Tel Aviv, Tall Abīb 6423906
Israel
Local Institution - 0194
Peatch Tikva, 49100
Israel
Local Institution - 0384
Meldola, Emilia-Romagna 47014
Italy
Local Institution - 0212
Rome, Roma 00189
Italy
Local Institution - 0160
Catania, Sicily 95123
Italy
Local Institution - 0159
Bologna, 40138
Italy
Local Institution - 0158
Pavia, 27100
Italy
National Cancer Center Hospital East
Kashiwa, Chiba 277-8577
Japan
Japan Community Healthcare Organization Kyushu Hospital
Kitakyushu-shi, Fukuoka 806-8501
Japan
Local Institution - 0280
Sapporo, Hokkaido 003-0804
Japan
Mito Medical Center
Higashiibaraki, Ibaraki 3113117
Japan
Local Institution - 0276
Shiwa-gun Yahaba-cho, Iwate 028-3695
Japan
Shonan Kamakura General Hospital
Kamakura, Kanagawa 247-8533
Japan
Saitama Medical University Hospital
Iruma, Saitama 350-0495
Japan
Dokkyo Medical University Saitama Medical Center
Koshigaya, Saitama 3438555
Japan
Shizuoka Cancer Center
Nagaizumi-cho,Sunto-gun, Shizuoka 411-8777
Japan
Local Institution - 0296
Itabashiku, Tokyo 173-8610
Japan
Local Institution - 0283
Shibuya-ku, Tokyo 150-8935
Japan
Chiba University Hospital
Chiba, 260-8677
Japan
National Hospital Organization Kyushu Medical Center
Fukuoka, 810-8563
Japan
Japanese Red Cross Fukuoka Hospital
Fukuoka, 815-8555
Japan
Local Institution - 0291
Hiroshima, 730-8619
Japan
Local Institution - 0284
Kumamoto, 860-8556
Japan
Local Institution - 0277
Nagasaki, 852-8511
Japan
The Jikei University Hospital
Tokyo, 105-000
Japan
Local Institution - 0335
Tauranga, Bay of Plenty 3112
New Zealand
Local Institution - 0340
Dunedin, Otago 9016
New Zealand
Local Institution - 0369
Auckland, 1023
New Zealand
Local Institution - 0334
Auckland, 2025
New Zealand
Local Institution - 0346
Skórzewo, Greater Poland Voivodeship 60-185
Poland
Local Institution - 0224
Torun, Kuyavian-Pomeranian Voivodeship 87-100
Poland
Local Institution - 0325
Krakow, Lesser Poland Voivodeship 30-727
Poland
Local Institution - 0250
Warsaw, Masovian Voivodeship 02-776
Poland
Local Institution - 0292
Słupsk, Pomeranian Voivodeship 76-200
Poland
Local Institution - 0185
Katowice, 40-519
Poland
Hospital de Braga
Braga, 4710-243
Portugal
Champalimaud Foundation
Lisbon, 1400-038
Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
Porto, 4200-072
Portugal
Local Institution - 0355
San Juan, 00909
Puerto Rico
Local Institution - 0021
Bucharest, 022328
Romania
Local Institution - 0052
Cluj-Napoca, 400124
Romania
Local Institution - 0035
Iași, 700483
Romania
Netcare Pretoria East Hospital
Centurion, GP 0044
South Africa
Groote Schuur Hospital
Cape Town, Western Cape 7925
South Africa
Haemalife
Kuilsriver, Western Cape 7580
South Africa
Constantiaberg Haematology
Plumstead, Western Cape 7800
South Africa
Local Institution - 0106
Busan, Busan 49241
South Korea
Pusan National University Hospital
Busan, Busan 49241
South Korea
Local Institution - 0102
Seongnam, Gyeonggido 13620
South Korea
Seoul National University Bundang Hospital
Seongnam, Gyeonggido 13620
South Korea
Chonnam National University Hwasun Hospital
Hwasun, Jeonranamdo 58128
South Korea
Local Institution - 0103
Hwasun, Jeonranamdo 58128
South Korea
Local Institution - 0101
Seoul, Seoul Teugbyeolsi 03080
South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi 03080
South Korea
Samsung Medical Center
Seoul, Seoul Teugbyeolsi 06351
South Korea
Local Institution - 0104
Seoul, Seoul Teugbyeolsi 06591
South Korea
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, Seoul Teugbyeolsi 06591
South Korea
Asan Medical Center
Seoul, Seoul-teukbyeolsi [Seoul] 05505
South Korea
Local Institution - 0105
Seoul, Seoul-teukbyeolsi 05505
South Korea
Local Institution - 0100
Seoul, 03722
South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722
South Korea
Local Institution
Seoul, 138-736
South Korea
Local Institution - 0183
Palma, Balearic Islands 07120
Spain
Local Institution - 0252
Palma, Balears [Baleares] 07120
Spain
Local Institution - 0073
Barcelona, Catalunya [Cataluña] 08036
Spain
Local Institution - 0210
Barcelona, Catalunya [Cataluña] 08036
Spain
Local Institution - 0075
Murcia, Murcia, Región de 30008
Spain
Local Institution - 0182
Marbella, Málaga 29603
Spain
Local Institution - 0253
Marbella, Málaga 29603
Spain
Local Institution - 0328
Cáceres, 10003
Spain
Local Institution - 0074
León, 24071
Spain
Local Institution - 0181
Madrid, 28041
Spain
Local Institution - 0232
Ankara, 06620
Turkey (Türkiye)
Local Institution - 0339
Ankara, 06680
Turkey (Türkiye)
Local Institution - 0228
Istanbul, 34093
Turkey (Türkiye)
Local Institution - 0229
Izmir, 35100
Turkey (Türkiye)
Local Institution - 0226
Kayseri, 0
Turkey (Türkiye)
Local Institution - 0227
Samsun, 55139
Turkey (Türkiye)
Addenbrooke's Hospital
Cambridge, Cambridgeshire CB2 0QQ
United Kingdom
The Royal Cornwall Hospital
Truro, England TR1 3LJ
United Kingdom
Lanarkshire NHS Trust - Monklands Hospital
Airdrie, Great Britain ML6 OJS
United Kingdom
King's College Hospital
London, Greater London SE5 9RS
United Kingdom
Leicester Royal Infirmary
Leicester, Leicestershire LE1 5WW
United Kingdom
Hammersmith Hospital
London, London, City of W12 0HS
United Kingdom
Barnet Hospital
Barnet, EN5 3DJ
United Kingdom
Freeman Hospital
Newcastle upon Tyne, NE7 7DN
United Kingdom
Royal Stoke University Hospital
Stoke-on-Trent, ST4 6QG
United Kingdom