A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
Start Date
2/20/2024
Completion Date
3/9/2028
Summary
The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide. There are 2 parts to this study. Part 1 will look at how safe and tolerable is elranatamab when given with iberdomide. Part 2 will look at the correct amount of this combination that can be given to patients with relapsed or refractory multiple myeloma. Myeloma is a type of cancer that begins in plasma cells (white blood cells that produce antibodies). Refractory means a disease or condition that does not respond to treatment. Relapsed means the return of a disease after a period of improvement. All study medicines are given in cycles that last 28 days. Everyone taking part in this study will receive elranatamab as a shot under the skin. Iberdomide will be taken by mouth once a day for 21 days over a 28-day cycle. Participants will receive study medicine until: * their disease progresses or, * they experience unacceptable side effects or, * they choose to no longer take part in the study. The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and can be used for multiple myeloma treatment.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Elranatamab
Iberdomide
Conditions
Locations
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
Coral Gables, Florida 33146
United States
University of Miami Hospital and Clinics Deerfield Beach
Deerfield Beach, Florida 33442
United States
Sylvester Comprehensive Cancer Center- Doral
Doral, Florida 33166
United States
Sylvester Comprehensive Cancer Center
Miami, Florida 33136
United States
University of Miami Hospital and Clinics
Miami, Florida 33136
United States
Sylvester Comprehensive Cancer Center Kendall
Miami, Florida 33176
United States
Sylvester Comprehensive Cancer Center Plantation
Plantation, Florida 33324
United States
Emory University Hospital Midtown
Atlanta, Georgia 30308
United States
Emory University Hospital
Atlanta, Georgia 30322
United States
Winship Cancer Institute
Atlanta, Georgia 30322
United States
Indiana CTSI Clinical Research Center (ICRC)
Indianapolis, Indiana 46202
United States
Indiana University Health University Hospital
Indianapolis, Indiana 46202
United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC)
Indianapolis, Indiana 46202
United States
University of Maryland
Baltimore, Maryland 21201
United States
Brigham and Women's Hospital
Boston, Massachusetts 02115
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Dana-Farber Cancer Institute - Chestnut Hill
Newton, Massachusetts 02459
United States
University of Massachusetts Chan Medical School
Worcester, Massachusetts 01655
United States
Methodist Hospital
Omaha, Nebraska 68114
United States
Oncology Hematology West P.C. dba Nebraska Cancer - Methodist
Omaha, Nebraska 68114
United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
Omaha, Nebraska 68130
United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire 03756
United States
MSK Basking Ridge
Basking Ridge, New Jersey 07920
United States
MSK Monmouth
Middletown, New Jersey 07748
United States
MSK Bergen
Montvale, New Jersey 07645
United States
MSK Commack
Commack, New York 11725
United States
MSK Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
Long Island City, New York 11101
United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
New York, New York 10021
United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York 10065
United States
MSK Nassau
Uniondale, New York 11553
United States
Fred Hutchinson Cancer Center
Seattle, Washington 98109
United States
University of Washington
Seattle, Washington 98195
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Liverpool Hospital
Liverpool, New South Wales 2170
Australia
Calvary Mater Newcastle
Waratah, New South Wales 2298
Australia
Townsville University Hospital
Douglas, Queensland 4814
Australia
Epworth Freemasons
East Melbourne, Victoria 3002
Australia
Epworth Hospital
Richmond, Victoria 3121
Australia
Slade Pharmacy
Richmond, Victoria 3121
Australia
Dr. Everett Chalmers Regional Hospital
Fredericton, New Brunswick E3B 5N5
Canada
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Quebec H1T 2M4
Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
Sherbrooke, Quebec J1H 5N4
Canada