A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Start Date
12/16/2024
Completion Date
12/26/2030
Summary
The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Amivantamab
Lazertinib
Chemotherapy: Pemetrexed
Chemotherapy: Carboplatin
Conditions
Locations
Southern Cancer Center, PC
Daphne, Alabama 36526
United States
Clearview Cancer Institute
Huntsville, Alabama 35805
United States
City of Hope Phoenix
Goodyear, Arizona 85338
United States
The Oncology Institute of Hope and Innovation
Cerritos, California 90703
United States
City of Hope Corona
Corona, California 92882
United States
City of Hope
Duarte, California 91010
United States
Providence Medical Foundation
Fullerton, California 92835
United States
Oncology Physicians Network Healthcare
Glendale, California 91203
United States
Los Angeles Cancer Network
Glendale, California 91204
United States
Glendale Adventist Medical Center
Glendale, California 91206
United States
Marin Cancer Center
Greenbrae, California 94904
United States
City of Hope Seacliff
Huntington Beach, California 92648
United States
City of Hope Orange County Lennar Foundation Cancer Center
Irvine, California 92618
United States
University of California San Diego Health
La Jolla, California 92093
United States
City of Hope Antelope Valley
Lancaster, California 93534
United States
City of Hope Long Beach Elm
Long Beach, California 90813
United States
Cancer and Blood Specialty Clinic
Los Alamitos, California 90720
United States
USC Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
Cedars Sinai Medical Center
Los Angeles, California 90048
United States
Valkyrie Clinical Trials
Los Angeles, California 90067
United States
Valkyrie Clinical Trials Murrieta
Murrieta, California 92562
United States
Kaiser Permanente Oakland Medical Center
Oakland, California 94611
United States
St. Joseph Hospital Center for Cancer Prevention and Treatment
Orange, California 92868
United States
University of California Irvine
Orange, California 92868
United States
Sutter Health Palo Alto Medical Foundation
Palo Alto, California 94301
United States
Kaiser Permanente Roseville Medical Center
Roseville, California 95661
United States
UC Davis Comprehensive Cancer Center
Sacramento, California 95630
United States
Sutter Institute for Medical Research
Sacramento, California 95816
United States
California Pacific Medical Center
San Francisco, California 94115
United States
Kaiser Permanente San Francisco Medical Center
San Francisco, California 94115
United States
UCSF Zuckerberg San Francisco General Hospital
San Francisco, California 94143
United States
Sansum Clinic
Santa Barbara, California 93105
United States
Kaiser Permanente Santa Clara Medical Center
Santa Clara, California 95051
United States
Providence Medical Foundation 1
Santa Rosa, California 95403
United States
City of Hope South Pasadena
South Pasadena, California 91030
United States
City of Hope Upland
Upland, California 91786
United States
Kaiser Permanente Northern California
Vallejo, California 94589
United States
Kaiser Permanente Walnut Creek Medical Center
Walnut Creek, California 94596
United States
John Muir Health Clinical Research Center
Walnut Creek, California 94598
United States
National Jewish Health
Denver, Colorado 80206
United States
Saint Josephs Hospital Cancer Centers of Colorado
Denver, Colorado 80218
United States
Lutheran Hospital Cancer Centers of Colorado
Golden, Colorado 80401
United States
Rocky Mountain Cancer Centers
Lone Tree, Colorado 80124
United States
Yale New Haven Hospital Yale Cancer Center
New Haven, Connecticut 06520
United States
ChristianaCare Helen F Graham Cancer Center and Research Institute
Newark, Delaware 19713
United States
MedStar Georgetown University Hospital
Washington D.C., District of Columbia 20007
United States
Washington DC VA Medical Center
Washington D.C., District of Columbia 20422
United States
Baptist Lynn Cancer Institute
Boca Raton, Florida 33486
United States
The Oncology Institute of Hope and Innovation 1
Fort Lauderdale, Florida 33316
United States
Florida Cancer Specialists
Fort Myers, Florida 33916
United States
Univ of Florida
Gainesville, Florida 32610
United States
Memorial Regional Hospital
Hollywood, Florida 33021 5421
United States
Baptist MD Anderson Cancer Center
Jacksonville, Florida 32207
United States
Mayo Clinic
Jacksonville, Florida 32224
United States
Sylvester Comprehensive Cancer Center
Miami, Florida 33136
United States
Baptist Health Miami Cancer Institute
Miami, Florida 33176
United States
AdventHealth Orlando
Orlando, Florida 32803
United States
Orlando Health Cancer Institute
Orlando, Florida 32806
United States
Memorial Cancer Institute
Pembroke Pines, Florida 33026
United States
Florida Cancer Specialists & Research Institute 1
St. Petersburg, Florida 33701
United States
Moffitt Cancer Center
Tampa, Florida 33612
United States
Florida Cancer Specialists & Research Institute
West Palm Beach, Florida 33401
United States
University Cancer And Blood Center LLC
Athens, Georgia 30607
United States
Grady Health System Correll Pavilion
Atlanta, Georgia 30303
United States
Piedmont Healthcare
Atlanta, Georgia 30309
United States
Piedmont Cancer Institute
Atlanta, Georgia 30318
United States
Winship Cancer Institute Emory University
Atlanta, Georgia 30322
United States
City of Hope Cancer Center
Newnan, Georgia 30265
United States
Rush University Medical Center Rush University Cancer Center Chicago
Chicago, Illinois 60607
United States
University of Illinois at Chicago
Chicago, Illinois 60612
United States
Cancer Care Specialists of Central Illinois
Decatur, Illinois 62526
United States
Hope and Healing Cancer Services
Hinsdale, Illinois 60521
United States
Illinois Cancer Specialists
Niles, Illinois 60714
United States
Illinois CancerCare
Peoria, Illinois 61615
United States
City of Hope Chicago
Zion, Illinois 60099
United States
Fort Wayne Medical Oncology and Hematology
Fort Wayne, Indiana 46804
United States
Investigative Clinical Research of Indiana, LLC
Noblesville, Indiana 46062
United States
Accellacare of McFarland
Ames, Iowa 50010
United States
University of Kansas Cancer Center
Fairway, Kansas 66205
United States
University of Maryland
Baltimore, Maryland 21201
United States
Maryland Oncology Hematology P A
Silver Spring, Maryland 20904
United States
Boston University Medical Center
Boston, Massachusetts 02118
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
United States
Dana Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan Health System
Ann Arbor, Michigan 48105
United States
Trinity Health St Joseph Mercy Ann Arbor
Ypsilanti, Michigan 48197
United States
University Of Minnesota
Minneapolis, Minnesota 55455
United States
Mayo Clinic Rochester
Rochester, Minnesota 55905
United States
Jackson Oncology Associates
Jackson, Mississippi 39202
United States
Truman Medical Ctr West
Kansas City, Missouri 64108
United States
Oncology Hematology Associates
Springfield, Missouri 65807
United States
Washington University School Of Medicine
St Louis, Missouri 63110
United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire 03756
United States
Hunterdon Hematology Oncology
Flemington, New Jersey 08822
United States
Morristown Medical Center
Morristown, New Jersey 07960
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08901
United States
Overlook Medical Center
Summit, New Jersey 07901
United States
Holy Name Medical Center
Teaneck, New Jersey 07666
United States
University of New Mexico
Albuquerque, New Mexico 87102
United States
Hematology-Oncology Associates of CNY
East Syracuse, New York 13057
United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York 11501
United States
NYU Langone Health Laura and Isaac Perlmutter Cancer Center
New York, New York 10016
United States
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
New York, New York 10032
United States
Ellis Hospital
Schenectady, New York 12308
United States
New York Cancer and Blood Specialists
Shirley, New York 11967
United States
Montefiore Medical Center
The Bronx, New York 10461
United States
Clinical Research Alliance Inc
Westbury, New York 11590
United States
Atrium Health
Charlotte, North Carolina 28204
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Regional Medical Oncology Center
Wilson, North Carolina 27893
United States
Atrium Health Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina 27157
United States
University of Cincinnati
Cincinnati, Ohio 45219
United States
Cincinnati Veterans Affairs Medical Center
Cincinnati, Ohio 45220
United States
Oncology Associates of Oregon PC Willamette Valley Cancer Institute
Eugene, Oregon 97401
United States
Oregon Health And Science University
Portland, Oregon 97239
United States
Lankenau Institute for Medical Research Main Line Health Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010
United States
Lankenau Institute for Medical Research Main Line Health Paoli Hospital
Paoli, Pennsylvania 19301
United States
Philadelphia VA Medical Center
Philadelphia, Pennsylvania 19104
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Jefferson Health Northeast
Philadelphia, Pennsylvania 19114
United States
McGlinn Cancer Institute Reading Hospital
West Reading, Pennsylvania 19611
United States
Lankenau Institute for Medical Research
Wynnewood, Pennsylvania 19096
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Avera Medical Group
Sioux Falls, South Dakota 57105
United States
Tennessee Oncology - Chattanooga
Chattanooga, Tennessee 37404
United States
Tennessee Cancer Specialists
Knoxville, Tennessee 37909
United States
University of Tennessee
Knoxville, Tennessee 37920
United States
Baptist Cancer Center
Memphis, Tennessee 38120
United States
SCRI Oncology Partners
Nashville, Tennessee 37203
United States
Tennessee Oncology
Nashville, Tennessee 37203
United States
Texas Oncology South
Austin, Texas 78745
United States
Parkland Health and Hospital System
Dallas, Texas 75235
United States
Texas Oncology DFW
Dallas, Texas 75246
United States
UT Southwestern Medical Center
Dallas, Texas 75390
United States
Renovatio Clinical
El Paso, Texas 79915
United States
JPS Health Network
Fort Worth, Texas 76104
United States
MD Anderson Cancer Center
Houston, Texas 77030
United States
Oncology Consultants Texas
Houston, Texas 77030
United States
Texas Oncology Odessa-West Texas Cancer Center
Odessa, Texas 79761
United States
Texas Oncology San Antonio Northeast
San Antonio, Texas 78217
United States
Community Clinical Trials
Spring, Texas 77389
United States
Renovatio Clinical 1
The Woodlands, Texas 77380
United States
The University of Texas Health Science Center at Tyler
Tyler, Texas 75701
United States
Texas Oncology - Northeast
Tyler, Texas 75702
United States
Texas Oncology-Gulf Coast
Webster, Texas 77598
United States
Huntsman Cancer Institute
Salt Lake City, Utah 84112
United States
Virginia Cancer Specialists
Fairfax, Virginia 22031
United States
Vista Oncology
Olympia, Washington 98506
United States
Summit Cancer Centers
Spokane, Washington 99208
United States
Northwest Cancer Specialists - Vancouver
Vancouver, Washington 98684
United States
Ziekenhuis Oost-Limburg
Genk, 3600
Belgium
Ghent University Hospital
Ghent, 9000
Belgium
Universitair Ziekenhuis Leuven
Leuven, 3000
Belgium
CHU UCL Namur - Site Godinne
Yvoir, 5530
Belgium
Helsinki University Hospital
Helsinki, 00290
Finland
Oulu University Hospital
Oulu, 90220
Finland
Turku University Hospital
Turku, 20521
Finland
CHU de Brest - Hopital de la Cavale Blanche
Brest, 29200
France
CHU de Grenoble
La Tronche, 38700
France
Assistance Publique Hopitaux de Marseille (AP-HM) - Hopital
Marseille, 13005
France
I.C.O. Rene Gauducheau
Saint-Herblain, 44805
France
Universitätsmedizin Greifswald
Greifswald, 17489
Germany
St. Elisabeth Hospital Leipzig
Leipzig, 04277
Germany
Klinikum der Universitaet Muenchen
München, 80336
Germany
Katharinenhospital Innere Medizin
Stuttgart, 70174
Germany
Henry Dunant Hospital Center
Athens, 115 26
Greece
Thoracic General Hospital Of Athens I Sotiria
Athens, 11527
Greece
Metaxa Cancer Center Hospital Of Piraeus
Piraeus, 18537
Greece
Anticancer Hospital of Thessaloniki Theageneio
Thessaloniki, 546 39
Greece
Athens Medical Center S A Interbalkan Medical Center of Thessaloniki
Thessaloniki, 54639
Greece
Soroka Medical Center
Beersheba, 8457108
Israel
Rambam Medical Center
Haifa, 3109601
Israel
Meir Medical Center
Kfar Saba, 44281
Israel
Sheba Medical Center
Ramat Gan, 5262000
Israel
Aou San Luigi Gonzaga
Orbassano, 10043
Italy
Istituto Oncologico Veneto - IRCCS
Padova, 35128
Italy
Ospedale S. Maria Delle Croci
Ravenna, 48121
Italy
Fondazione Policlinico Universitario A Gemelli IRCCS
Roma, 00168
Italy
Istituto Clinico Humanitas
Rozzano, 20089
Italy
Centrum Onkologii im Prof F Lukaszczyka
Bydgoszcz, 85 796
Poland
Centrum Pulmonologii i Torakochirurgii w Bystrej
Bystra, 43 360
Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, 80 952
Poland
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie
Olsztyn, 10-357
Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
Warsaw, 02-781
Poland
Uls Braga - Hosp. Braga
Braga, 4710 243
Portugal
Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes
Guimarães, 4835 044
Portugal
Hosp. Cuf Tejo
Lisbon, 1350-352
Portugal
Uls Loures Odivelas - Hosp. Loures
Loures, 2674 514
Portugal
Ipo Porto
Porto, 4200 072
Portugal
Uls Gaia Espinho
Vila Nova de Gaia, 4434 502
Portugal
Auxilio Mutuo Cancer Center
San Juan, 00918
Puerto Rico
King Saud University Medical City
Riyadh, 12372
Saudi Arabia
Hosp Univ Vall D Hebron
Barcelona, 08035
Spain
Hosp. de Jerez de La Frontera
Jerez de la Frontera, 11407
Spain
Hosp. Univ. 12 de Octubre
Madrid, 28041
Spain
Hosp. Clinico Univ. de Santiago
Santiago de Compostela, 15706
Spain
Hosp. Univ. I Politecni La Fe
Valencia, 46026
Spain
Guy's and St Thomas' NHS Foundation Trust
Greater London, SE1 9RT
United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool, L78YA
United Kingdom
Royal Marsden Hospital 1
London, SW3 6JJ
United Kingdom
The Christie NHS Foundation Trust Christie Hospital
Manchester, M20 4BX
United Kingdom
Royal Marsden Hospital
Sutton, SM2 5PT
United Kingdom
Torbay Hospital-Devon
Torquay, TQ2 7AA
United Kingdom