Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus
Start Date
5/18/2026
Completion Date
10/1/2027
Summary
This study is a Phase 2 clinical trial to evaluate the efficacy, safety, and tolerability of HM15275 in subjects with type 2 diabetes mellitus over 36 weeks.
Detailed Description
HM-OBCT-202 is a Phase 2, randomized, double-blind, placebo-controlled, multicenter, parallel-group study designed to evaluate the efficacy, safety, and tolerability of HM15275 treatment over 36 weeks in adults with type 2 diabetes mellitus (T2DM). The study will enroll adult participants with T2DM (aged 18 to 75 years) who have inadequate glycemic control. Eligible participants must have a body mass index (BMI) ≥25 kg/m² and ≤50 kg/m² and HbA1c between 7.0% and 10.0% at screening. Participants in this study will be randomly assigned in a 1:1:1:1 ratio to 1 of the 4 treatment arms. Randomization will be stratified by screening HbA1c (≤8.0% versus \>8.0%) and use of metformin (yes versus no). All participants will undergo a 4-week screening period, a 36-week treatment period (including weekly subcutaneous \[SC\] injection of study drug), and a 4-week safety follow-up period.
Eligibility Criteria
Age Range: 18 years to 75 years
Interventions
HM15275
Placebo of HM15275
Conditions
Locations
Desert Clinical Research
Mesa, Arizona 85123
United States
Charter Research
Orlando, Florida 32803
United States
AdventHealth Translational Research Institute
Orlando, Florida 32804
United States
Centricity Research IRT - DBA IACT Health Columbus Piedmont
Columbus, Georgia 31904
United States
The South Bend Clinic
South Bend, Indiana 46617
United States
Jefferson City Medical Center
Jefferson City, Missouri 65109
United States
Clay Platte Family Medicine
Kansas City, Missouri 64151
United States
Methodist Physicians Clinic
Fremont, Nebraska 68025
United States
Santa Rosa Medical Centers of Nevada
Las Vegas, Nevada 89119
United States
Lucas Research, Inc.
Morehead City, North Carolina 28557
United States
Centricity Research Columbus
Columbus, Ohio 43213
United States
Olympus Family Medicine
Salt Lake City, Utah 84117
United States
Manassas Clinical Research Center
Manassas, Virginia 20110
United States